Miller L, Pateras V, Friederici H, Engel G
Arch Intern Med. 1985 Jan;145(1):145-6.
Nephrotoxic reaction occurred after inhalation exposure to methylene chloride. This exposure is associated with acute renal failure, myoglobinuria, hypocomplementemia, and liver enzyme elevations. Pathologic specimens, both light and electron microscopic, demonstrate renal tubular damage. We conclude that methylene chloride may have potential as both a hepatotoxic and nephrotoxic agent when inhaled at high concentrations over an extended period of time.
吸入二氯甲烷后发生肾毒性反应。这种接触与急性肾衰竭、肌红蛋白尿、补体血症降低和肝酶升高有关。光学显微镜和电子显微镜下的病理标本均显示肾小管损伤。我们得出结论，长时间高浓度吸入二氯甲烷时，它可能具有肝毒性和肾毒性。
