Zhang Qianqian, Li Wen, Yu Sheng, Xu Jian, Tang Lingxue, Yao Senbang, Cheng Huaidong
Department of Oncology, The Second Hospital of Anhui Medical University, Hefei, China.
Shenzhen Clinical Medical School of Southern Medical University, Shenzhen, China; Department of Oncology, Shenzhen Hospital of Southern Medical University, Guangdong, Shenzhen, China.
Clin Breast Cancer. 2025 Apr;25(3):233-241. doi: 10.1016/j.clbc.2024.11.014. Epub 2024 Nov 28.
To explore the correlation between heart rate variability (HRV), peripheral cytokines, anxiety and pain scores in patients with breast cancer (BC).
We collected blood samples from 100 BC patients and measured the concentrations of Interleukin 6 (IL-6), Interleukin 4 (IL-4) and Interferon gamma (IFN-γ). We collected the patients' 5-minute dynamic electrocardiograms and evaluated their anxiety and pain levels through the Anxiety Self-Rating Scale and the Short-Form McGill Pain Questionnaire (SF-MPQ) Scale.
Compared with patients in the high HRV group, the low HRV group had lower IL-4 levels and higher IFN-γ/IL-4 concentrations. At the same time, the level of anxiety was also higher, but there was no significant difference in pain. Spearman correlation analysis showed that the normal-to-normal cardiac intervals (SDNN), the square root of the mean of the sum of the squares of differences between adjacent normal-to-normal cardiac intervals (RMSSD), high frequency -HRV (HF-HRV) and IL-4 were positively correlated, SDNN and RMSSD were negatively correlated with IFN-γ/IL-4. HRV is negatively correlated with anxiety. Higher SDNN predicts higher IL-4 levels.
Our results indicate that BC patients with low HRV are associated with higher levels of inflammation and anxiety. Therefore, the measurement of HRV may serve as an objective and non-invasive measurement method for monitoring the immune system and anxiety problems of BC patients.
探讨乳腺癌（BC）患者心率变异性（HRV）、外周细胞因子、焦虑与疼痛评分之间的相关性。
我们收集了100例BC患者的血样，测量白细胞介素6（IL-6）、白细胞介素4（IL-4）和干扰素γ（IFN-γ）的浓度。我们收集了患者5分钟的动态心电图，并通过焦虑自评量表和简化麦吉尔疼痛问卷（SF-MPQ）量表评估他们的焦虑和疼痛水平。
与高HRV组患者相比，低HRV组的IL-4水平较低，IFN-γ/IL-4浓度较高。同时，焦虑水平也较高，但疼痛方面无显著差异。Spearman相关性分析显示，正常到正常心搏间期（SDNN）、相邻正常到正常心搏间期差值平方和均值的平方根（RMSSD）、高频-HRV（HF-HRV）与IL-4呈正相关，SDNN和RMSSD与IFN-γ/IL-4呈负相关。HRV与焦虑呈负相关。较高的SDNN预示着较高的IL-4水平。
我们的结果表明，HRV低的BC患者与更高水平的炎症和焦虑相关。因此，HRV的测量可能作为一种客观且无创的测量方法，用于监测BC患者的免疫系统和焦虑问题。
