School of Medical Imaging, Bengbu Medical College, Bengbu, 233030, Anhui, China.
Anhui Key Laboratory of Computational Medicine and Intelligent Health, Bengbu Medical College, Bengbu, 233030, Anhui, China.
Sci Rep. 2021 Jul 29;11(1):15414. doi: 10.1038/s41598-021-94931-w.
The purpose of this study was to investigate the relationship between heart rate variability (HRV), a non-invasive tool for evaluating autonomic function, and routine coagulation indices (RCIs) in patients with breast cancer (BC). Forty-six BC patients were enrolled in this study. Blood biochemistry tests were performed to extract RCIs, including prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT). Five-minute electrocardiograms were collected for analysis of HRV parameters (SDNN, RMSSD, LF, HF, LF n.u., HF n.u., LF/HF). Multiple linear regression models examined the relationship of HRV parameters with RCIs. RMSSD, LF n.u., HF n.u., LF/HF were significantly associated with PT. Specifically, the value of PT increased by 0.192 ± 0.091 or 0.231 ± 0.088 s, respectively for each 1 standard deviation (SD) increase in RMSSD or HF n.u.; it increased by 0.230 ± 0.088 or 0.215 ± 0.088 s, respectively for each 1 - SD decrease in LF n.u. or ln (LF/HF) (all P < 0.05). RMSSD was significantly associated with APTT, i.e., the value of APTT increased by 1.032 ± 0.470 s for each 1 - SD increase in RMSSD (P < 0.05). HRV parameters were associated with RCIs in patients with BC. These observations suggest that the autonomic nervous system and coagulation indices in BC patients are linked, potentially explaining the reason that they are both associated with the prognosis.
本研究旨在探讨心率变异性（HRV）——一种评估自主神经功能的非侵入性工具——与乳腺癌（BC）患者常规凝血指标（RCIs）之间的关系。本研究纳入了 46 例 BC 患者。进行血液生化测试以提取 RCIs，包括凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和凝血时间（TT）。采集 5 分钟心电图用于分析 HRV 参数（SDNN、RMSSD、LF、HF、LF n.u.、HF n.u.、LF/HF）。多元线性回归模型探讨了 HRV 参数与 RCIs 的关系。RMSSD、LF n.u.、HF n.u.、LF/HF 与 PT 显著相关。具体而言，RMSSD 或 HF n.u.每增加 1 个标准差（SD），PT 值分别增加 0.192±0.091 或 0.231±0.088 s；LF n.u.或 ln（LF/HF）每减少 1 SD，PT 值分别增加 0.230±0.088 或 0.215±0.088 s（均 P<0.05）。RMSSD 与 APTT 显著相关，即 RMSSD 每增加 1 SD，APTT 值增加 1.032±0.470 s（P<0.05）。HRV 参数与 BC 患者的 RCIs 相关。这些观察结果表明，BC 患者的自主神经系统和凝血指标之间存在关联，这可能解释了它们与预后均相关的原因。
