Jia Xuechao, Huang Chuntian, Liu Fangfang, Dong Zigang, Liu Kangdong
Henan International Joint Laboratory of TCM Syndrome and Prescription in Signaling, Traditional Chinese Medicine (Zhong Jing) School, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan, China.
Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China.
Cell Mol Biol Lett. 2024 Dec 20;29(1):156. doi: 10.1186/s11658-024-00674-7.
Aberrant elongation of proteins can lead to the activation of oncogenic signaling pathways, resulting in the dysregulation of oncogenic signaling pathways. Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely elongates nascent peptides in the protein elongation process. Although studies have linked aberrant eEF2 expression to various cancers, research has primarily focused on its structure, highlighting a need for deeper exploration into its molecular functions. In this review, recent advancements in the structure, guanosine triphosphatase (GTPase) activity, posttranslational modifications, regulatory factors, and inhibitors of eEF2 are summarized. These findings provide a comprehensive cognition on the critical role of eEF2 and its potential as a therapeutic target in cancer. Furthermore, this review highlights important unanswered questions that warrant investigation in future research.
蛋白质的异常延伸可导致致癌信号通路的激活，进而造成致癌信号通路的失调。真核生物延伸因子2（eEF2）是蛋白质合成的关键调节因子，在蛋白质延伸过程中精确地延长新生肽链。尽管已有研究将eEF2的异常表达与多种癌症联系起来，但研究主要集中在其结构上，这凸显了对其分子功能进行更深入探索的必要性。在本综述中，总结了eEF2在结构、鸟苷三磷酸酶（GTPase）活性、翻译后修饰、调节因子及抑制剂方面的最新进展。这些发现为eEF2的关键作用及其作为癌症治疗靶点的潜力提供了全面的认识。此外，本综述还强调了一些重要的未解决问题，值得在未来的研究中进行探讨。
