白细胞与血红蛋白比值作为预测重症监护病房肺动脉高压患者30天死亡率的指标：一项MIMIC-IV数据库研究

White blood cell-to-haemoglobin ratio as a predictor of 30-day mortality in ICU patients with pulmonary hypertension: a MIMIC-IV database study.

作者信息

Li Shuangping, Huang Shenshen, Feng Yuxuan, Mao Yimin

机构信息

College of Clinical Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.

出版信息

BMC Cardiovasc Disord. 2024 Dec 20;24(1):729. doi: 10.1186/s12872-024-04396-8.

DOI:10.1186/s12872-024-04396-8

PMID:39707222

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11660688/

Abstract

BACKGROUND AND OBJECTIVE

The white blood cell-to-haemoglobin ratio (WHR) is a comprehensive indicator of inflammation and anaemia status. However, the relationship between the WHR and the risk of 30-day mortality among intensive care unit (ICU) patients with pulmonary hypertension (PH) remains unclear. The purpose of this study was to investigate the association between the WHR and 30-day mortality in critically ill patients with PH.

METHODS

Clinical data of patients with PH were extracted from the MIMIC-IV (2.2) database. Restricted cubic splines and logistic regression analysis were used to investigate the relationship between the WHR and 30-day mortality. Subgroup analysis was used to assess the robustness of the results.

RESULTS

A total of 451 patients with PH were enrolled, with 78 (17.3%) dying within 30 days. Restricted cubic spline analysis revealed a linear relationship between the WHR and 30-day mortality. Logistic regression analysis revealed the WHR was an independent predictor for 30-day mortality in critically ill patients with PH (OR, 1.58; 95% CI, 1.05-2.37; P = 0.028). The AUC of the WHR was 0.646 (95% CI: 0.60-0.69).

CONCLUSIONS

A higher WHR was an independent predictor for 30-day mortality in critically ill patients with PH.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景与目的

白细胞与血红蛋白比值（WHR）是炎症和贫血状态的综合指标。然而，WHR与重症监护病房（ICU）中患有肺动脉高压（PH）患者的30天死亡率之间的关系仍不明确。本研究的目的是探讨WHR与PH危重症患者30天死亡率之间的关联。

方法

从MIMIC-IV（2.2）数据库中提取PH患者的临床资料。采用限制立方样条和逻辑回归分析来研究WHR与30天死亡率之间的关系。亚组分析用于评估结果的稳健性。

结果

共纳入451例PH患者，其中78例（17.3%）在30天内死亡。限制立方样条分析显示WHR与30天死亡率之间存在线性关系。逻辑回归分析显示，WHR是PH危重症患者30天死亡率的独立预测因素（OR，1.58；95%CI，1.05-2.37；P = 0.028）。WHR的AUC为0.646（95%CI：0.60-0.69）。