Wright Shaun A, Lennon Rachel, Greenhalgh Andrew D
Lydia Becker Institute of Immunology and Inflammation, Division, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Science, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Cell Matrix Biology & Regenerative Medicine and Wellcome Centre for Cell-Matrix Research, School of Biological Science, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
J Inflamm (Lond). 2024 Dec 20;21(1):53. doi: 10.1186/s12950-024-00426-6.
Basement membranes form part of the extracellular matrix (ECM), which is the structural basis for all tissue. Basement membranes are cell-adherent sheets found between cells and vascular endothelia, including those of the central nervous system (CNS). There is exceptional regional specialisation of these structures, both in tissue organisation and regulation of tissue-specific cellular processes. Due to their location, basement membranes perform a key role in immune cell trafficking and therefore are important in inflammatory processes causing or resulting from CNS disease and injury. This review will describe basement membranes in detail, with special focus on the brain. We will cover how genetic changes drive brain pathology, describe basement membranes' role in immune cell recruitment and how they respond to various brain diseases. Understanding how basement membranes form the junction between the immune and central nervous systems will be a major advance in understanding brain disease.
基底膜是细胞外基质（ECM）的一部分，而细胞外基质是所有组织的结构基础。基底膜是位于细胞与血管内皮之间的细胞粘附片层，包括中枢神经系统（CNS）中的那些。这些结构在组织组织和组织特异性细胞过程的调节方面都有特殊的区域特化。由于它们的位置，基底膜在免疫细胞运输中起关键作用，因此在导致中枢神经系统疾病和损伤或由中枢神经系统疾病和损伤引起的炎症过程中很重要。本综述将详细描述基底膜，特别关注大脑。我们将探讨基因变化如何驱动脑部病理学，描述基底膜在免疫细胞募集中的作用以及它们如何对各种脑部疾病作出反应。了解基底膜如何形成免疫和中枢神经系统之间的连接将是理解脑部疾病的一项重大进展。
