2型糖尿病患者肠道微生物群与超加工食品消费之间的关联：一项横断面研究。

Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study.

作者信息

Ichikawa Takahiro, Hashimoto Yoshitaka, Igarashi Yusuke, Kawai Sayaka, Kaji Ayumi, Sakai Ryosuke, Osaka Takafumi, Inoue Ryo, Kashiwagi Saori, Mizushima Katsura, Uchiyama Kazuhiko, Takagi Tomohisa, Naito Yuji, Hamaguchi Masahide, Fukui Michiaki

机构信息

Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.

Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, 5-55 Sotojima-Cho, Moriguchi, 570-8540, Japan.

出版信息

Nutr Metab (Lond). 2024 Dec 20;21(1):110. doi: 10.1186/s12986-024-00884-y.

DOI:10.1186/s12986-024-00884-y

PMID:39707434

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11662526/

Abstract

BACKGROUND

This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D).

METHODS

This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal). Gut microbial composition was evaluated via 16S rRNA gene sequencing. We investigated the association between gut microbiota, previously identified as relevant to T2D, and the density of UPFs intake using Spearman rank correlation coefficients. Multiple regression analysis, adjusting for age, sex, BMI, smoking status, exercise, and medication use, was conducted to further investigate these associations.

RESULTS

The mean age of participants was 68 (63-74) years. The density of UPFs intake showed significant associations with Bifidobacterium (r = 0.11, p = 0.031), Lactobacillus (r = 0.11, p = 0.046), Ruminococcus (r = -0.12, p = 0.019), Roseburia (r = 0.11, p = 0.045). After adjusting for covariates in multiple regression analysis, Ruminococcus and Roseburia showed modest negative (β = -0.11, p = 0.038) and positive (β = 0.12, p = 0.033) correlations, with the density of UPFs intake among participants with T2D, respectively.

CONCLUSIONS

The density of UPFs intake was modestly inversely associated with Ruminococcus among patients with T2D and modestly positively associated with Roseburia.

摘要

背景

本研究旨在探讨2型糖尿病（T2D）患者超加工食品（UPFs）消费与肠道微生物群之间的关系。

方法

这项横断面研究纳入了362名T2D患者。使用简短型自我管理饮食史问卷评估UPFs消费情况，以UPFs摄入量密度（克/1000千卡）进行量化。通过16S rRNA基因测序评估肠道微生物组成。我们使用Spearman等级相关系数研究先前确定与T2D相关的肠道微生物群与UPFs摄入量密度之间的关联。进行多元回归分析，对年龄、性别、BMI、吸烟状况、运动和药物使用进行校正，以进一步研究这些关联。

结果

参与者的平均年龄为68（63 - 74）岁。UPFs摄入量密度与双歧杆菌（r = 0.11，p = 0.031）、乳酸杆菌（r = 0.11，p = 0.046）、瘤胃球菌（r = -0.12，p = 0.019）、罗斯氏菌（r = 0.11，p = 0.045）存在显著关联。在多元回归分析中对协变量进行校正后，瘤胃球菌和罗斯氏菌分别与T2D患者的UPFs摄入量密度呈适度负相关（β = -0.11，p = 0.038）和正相关（β = 0.12，p = 0.033）。