Numao Shigeharu, Uchida Ryota, Nakagaichi Masaki
Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, 1 Shiromizu, Kanoya, Kagoshima, 891-2393, Japan.
Health and Sports Promotion Division, Sports Innovation Organization, National Institute of Fitness and Sports in Kanoya, 1 Shiromizu, Kanoya, Kagoshima, 891-2393, Japan.
J Physiol Anthropol. 2024 Dec 20;43(1):31. doi: 10.1186/s40101-024-00379-y.
Circulating fatty acid-binding protein 4 (FABP4) influences cardiovascular disease and glucose metabolism. Acute aerobic exercise increases circulating FABP4 concentrations, but the factors underlying this effect in humans are unclear. We investigated the effect of exercise duration on circulating FABP4 concentrations in healthy men.
This randomized crossover study enrolled healthy young men randomly assigned to two trials, short-duration (SE) and long-duration (LE) aerobic exercises trials. Both involved acute aerobic exercise followed by 60 min of bed rest. The exercise intensity was the same (40% peak oxygen uptake); however, the duration was 40 and 70 min for the SE and LE trials, respectively. Venous blood samples were collected to measure hormones, metabolites, and FABP4 concentrations.
Twelve healthy young men completed both trials. Changes in hormone levels did not differ significantly between the SE and LE trials (p > 0.05). However, the circulating FABP4 concentration increased significantly only in the LE trial immediately after exercise (p = 0.018). It increased significantly 30-60 min post-exercise in both the SE and LE trials (p < 0.018), with the extent of the increase being significantly higher in the LE trial than in the SE trial (p < 0.001). In each trial, the total incremental area under the curve of circulating FABP4 concentration was significantly positively correlated with body fat percentage (SE trial: r = 0.699, p = 0.019; LE trial: r = 0.643, p = 0.024).
Our findings suggest that exercise duration is associated with the magnitude of increased FABP4 secretion into the blood circulation. Body fat accumulation may also be involved in the magnitude of FABP4 secretion induced by acute aerobic exercise.
The study was pre-registered with the University Hospital Medical Information Network Center (UMIN), a clinical trial registration system (ID: UMIN000051068).
循环脂肪酸结合蛋白4（FABP4）影响心血管疾病和葡萄糖代谢。急性有氧运动可增加循环FABP4浓度，但人类中这种效应的潜在因素尚不清楚。我们研究了运动持续时间对健康男性循环FABP4浓度的影响。
这项随机交叉研究纳入了健康年轻男性，他们被随机分配到两项试验中，即短时间（SE）和长时间（LE）有氧运动试验。两项试验均包括急性有氧运动，随后卧床休息60分钟。运动强度相同（摄氧量峰值的40%）；然而，SE和LE试验的持续时间分别为40分钟和70分钟。采集静脉血样以测量激素、代谢物和FABP4浓度。
12名健康年轻男性完成了两项试验。SE和LE试验之间激素水平的变化无显著差异（p>0.05）。然而仅在LE试验中，运动后即刻循环FABP4浓度显著升高（p=0.018）。在SE和LE试验中，运动后第30 - 60分钟循环FABP4浓度均显著升高（p<0.018），且LE试验中升高幅度显著高于SE试验（p<0.001）。在每项试验中，循环FABP4浓度曲线下的总增量面积与体脂百分比显著正相关（SE试验：r=0.699，p=0.019；LE试验：r=0.643，p=0.024）。
我们的研究结果表明，运动持续时间与血液循环中FABP4分泌增加的幅度相关。体脂积累也可能参与急性有氧运动诱导的FABP4分泌幅度。
该研究已在大学医院医学信息网络中心（UMIN）进行预注册，UMIN是一个临床试验注册系统（ID：UMIN000051068）。
