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Oncostatin-M Is Produced by Human Eosinophils and Expression Is Increased in Uncontrolled Severe Asthma.

作者信息

Esnault Stephane, Bernau Ksenija, Floerke Heather L, Dendooven Arnaud, Delaunay Emeline, Dill-McFarland Kimberly A, Altman Matthew C, Busse William W, Rosenkranz Melissa A, Tattersall Matthew C, Johansson Mats W, Labreuche Julien, Beury Delphine, Sebda Shéhérazade, Dezoteux Frédéric, Segard Baptiste, Mortuaire Geoffrey, Staumont-Sallé Delphine, Stoup Thomas, Chenivesse Cécile, Sandbo Nathan, Jarjour Nizar N, Lefèvre Guillaume

机构信息

Univ. Lille, INSERM, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Lille, France.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

出版信息

Allergy. 2025 Apr;80(4):1154-1157. doi: 10.1111/all.16453. Epub 2024 Dec 21.

DOI:10.1111/all.16453
PMID:39707874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969300/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b7/11969300/62978fee2948/ALL-80-1154-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b7/11969300/c3a7bd98e1d0/ALL-80-1154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b7/11969300/62978fee2948/ALL-80-1154-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b7/11969300/c3a7bd98e1d0/ALL-80-1154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b7/11969300/62978fee2948/ALL-80-1154-g002.jpg

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本文引用的文献

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Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.证据表明，在伴有鼻息肉的慢性鼻-鼻窦炎中，抑瘤素 M 与 IL-4 信号协同作用诱导 TSLP 的表达。
J Allergy Clin Immunol. 2023 May;151(5):1379-1390.e11. doi: 10.1016/j.jaci.2022.11.029. Epub 2023 Jan 6.
2
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.细菌触发因素诱导的抑瘤素M表达驱动严重哮喘中的气道炎症和黏液分泌。
Sci Transl Med. 2022 Jan 12;14(627):eabf8188. doi: 10.1126/scitranslmed.abf8188.
3
Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge.
过敏原刺激后气道中白细胞介素 6（IL-6）的增加和潜在的 IL-6 转导信号。
Clin Exp Allergy. 2021 Apr;51(4):564-573. doi: 10.1111/cea.13832. Epub 2021 Feb 2.
4
Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling.免疫球蛋白 G 介导的嗜酸性粒细胞溶解与微管形成和 rho 相关蛋白激酶信号通路抑制有关。
Clin Exp Allergy. 2020 Feb;50(2):198-212. doi: 10.1111/cea.13538. Epub 2019 Dec 9.
5
RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism.肺原代成纤维细胞对嗜酸性粒细胞脱颗粒产物反应的 RNA 测序分析预测了对炎症、组织重塑和脂质代谢的下游影响。
Respir Res. 2017 Nov 10;18(1):188. doi: 10.1186/s12931-017-0669-8.
6
Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.中性粒细胞是黏膜气道疾病患者中破坏上皮屏障的细胞因子制瘤素M的主要来源。
J Allergy Clin Immunol. 2017 Jun;139(6):1966-1978.e9. doi: 10.1016/j.jaci.2016.10.039. Epub 2016 Dec 18.