52例人支气管和宫颈鳞状细胞癌中的肿瘤索：对其细胞动力学和放射生物学的推断
Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: inferences for their cellular kinetics and radiobiology.
作者信息
Moore J V, Hasleton P S, Buckley C H
出版信息
Br J Cancer. 1985 Mar;51(3):407-13. doi: 10.1038/bjc.1985.55.
Abstract
Tumour cords have been measured in 33 cases of squamous cell carcinoma (SCC) of the bronchus and 19 cases of SCC of the uterine cervix. The overall mean cord radius for SCC in both sites was 104 microns, similar to the overall mean for various tumours in rodents. For tumour cells adjacent to blood vessels in cords of SCC, the mean Mitotic Index was 2.1% and from this value a rapid potential doubling time could be inferred (approximately 31 to 66 h). The proportion of dead cells within cords of cervical SCC was higher than in animal tumours. Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC.
摘要
已对33例支气管鳞状细胞癌（SCC）和19例子宫颈鳞状细胞癌进行了肿瘤索测量。两个部位SCC的肿瘤索总体平均半径为104微米，与啮齿动物各种肿瘤的总体平均值相似。对于SCC肿瘤索中与血管相邻的肿瘤细胞，平均有丝分裂指数为2.1%，由此值可推断出快速潜在倍增时间（约31至66小时）。宫颈SCC肿瘤索内死细胞的比例高于动物肿瘤。利用测量的肿瘤索半径值和已发表的描述代谢组织中氧气扩散和消耗的方程，尝试计算这些SCC肿瘤索血管中的氧分压。
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