Shaaban Amira E, Ali Ahmed R, Ayyad Seif N, Badria Farid A
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt.
Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Bioorg Chem. 2025 Jan;154:108075. doi: 10.1016/j.bioorg.2024.108075. Epub 2024 Dec 17.
Complex diseases involve multifaceted etiological components, which limit the effectiveness of conventional targeted therapies. Therefore, standard medicinal treatments often face significant challenges and failures when addressing these disease conditions. Furthermore, the growing interest in multidrug resistance (MDR), the occurrence of adverse drug reactions related to use traditional approaches, and the limited clinical efficacy of single-target drug therapy have increased the demand for innovative drug treatments. In this rapidly evolving era, the exploration of multi-target directed ligands (MTDLs) derived from natural products has granted us access to a wide range of compounds with medicinal properties. The allure of these MTDLs lies in their unique ability to minimize side effects from using two medicinal agents, establishing them as the preferred choice for drug developers. MTDLs have been recognized for their extraordinary capacity to collectively hinder multiple pathways implicated in the development of intricate diseases by merging or linking active molecules obtained from these sources. This review delves into promising MTDLs derived from natural products, which modulates diverse biological pathways implicated in complex diseased conditions particularly Alzheimer's disease, diabetes, cardiac disorders and inflammatory conditions.
复杂疾病涉及多方面的病因成分，这限制了传统靶向治疗的效果。因此，标准药物治疗在应对这些疾病状况时往往面临重大挑战并遭遇失败。此外，对多药耐药性（MDR）的关注度不断提高、与传统治疗方法相关的药物不良反应的出现以及单靶点药物治疗有限的临床疗效，都增加了对创新药物治疗的需求。在这个快速发展的时代，对源自天然产物的多靶点导向配体（MTDLs）的探索使我们能够获得多种具有药用特性的化合物。这些MTDLs的魅力在于它们具有独特的能力，能够将使用两种药物的副作用降至最低，使其成为药物研发人员的首选。MTDLs因其非凡的能力而受到认可，即通过合并或连接从这些来源获得的活性分子，共同阻碍复杂疾病发展中涉及的多种途径。本综述深入探讨了源自天然产物的有前景的MTDLs，它们调节复杂疾病状态下涉及的多种生物途径，特别是阿尔茨海默病、糖尿病、心脏疾病和炎症性疾病。
