Moscucci Federica, Bucciarelli Valentina, Gallina Sabina, Sciomer Susanna, Mattioli Anna Vittoria, Maffei Silvia, Nodari Savina, Pedrinelli Roberto, Andreozzi Paola, Basili Stefania
Azienda Ospedaliera Universitaria Policlinico Umberto I, DAI of Internal Medicine and Medical Specialties, Viale del Policlinico n.155, 00185 Rome, Italy; Department of Clinical Medicine, Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Cardiovascular Sciences Department, Azienda Ospedaliero-Universitaria delle Marche, 60126 Ancona, Italy.
Maturitas. 2025 Feb;193:108170. doi: 10.1016/j.maturitas.2024.108170. Epub 2024 Dec 9.
Sleep-disordered breathing is a highly prevalent disorder with negative impact on healthcare systems worldwide. This condition has detrimental effects on cardiovascular health and quality of life, and is frequently associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes and atrial fibrillation. Nevertheless, it remains frequently undiagnosed and undertreated, especially in specific populations. Studies on sleep-disordered breathing have been conducted mainly on male patients, and the prevalence and severity of this disorder in women are underestimated. Recently, some clinical and laboratory evidence has highlighted the epidemiological and pathophysiological differences between men and women with sleep-disordered breathing. In this review, we discuss sex-related mechanisms of sleep-disordered breathing in frequently associated disorders, to improve clinical understanding of this condition and to simplify the practical application of targeted interventions. The aim is to improve prognosis among female patients and guarantee a better quality of life and a reduction in healthcare costs.
睡眠呼吸障碍是一种高度普遍的疾病，对全球医疗系统产生负面影响。这种情况对心血管健康和生活质量有不利影响，并且经常与多种合并症相关，包括心血管疾病、心力衰竭、糖尿病和心房颤动。然而，它仍然经常未被诊断和治疗不足，尤其是在特定人群中。关于睡眠呼吸障碍的研究主要在男性患者中进行，这种疾病在女性中的患病率和严重程度被低估。最近，一些临床和实验室证据突出了患有睡眠呼吸障碍的男性和女性在流行病学和病理生理学上的差异。在这篇综述中，我们讨论睡眠呼吸障碍在常见相关疾病中的性别相关机制，以提高对这种情况的临床认识，并简化针对性干预措施的实际应用。目的是改善女性患者的预后，确保更好的生活质量并降低医疗成本。
