Kerli Fernandes Elissa, Türck Patrick, Campos Carraro Cristina, Tasca Silvio, Teixeira Proença Isabel Cristina, Palma Victor De Mello, Visioli Fernanda, Torres Iraci Lucena Da Silva, Belló-Klein Adriane, Luz De Castro Alexandre, Da Rosa Araujo Alex Sander
Laboratory of Cardiovascular Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Oral Pathology Laboratory of the Faculty of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Arch Physiol Biochem. 2025 Jun;131(3):445-454. doi: 10.1080/13813455.2024.2441363. Epub 2024 Dec 22.
Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel therapeutic approach. This study explored the cardioprotective role of BOL in adverse left ventricular remodelling induced by isoproterenol. The rats were divided into four groups: control; BOL (25 mg/kg daily); isoproterenol (ISO) (5 mg/kg daily), and ISO + BOL. Morphometric, echocardiographic, and oxidative stress parameters were evaluated. BOL attenuated both cardiac hypertrophy and increased diastolic volume caused by adrenergic overstimulation (P < 0.05). BOL treatment reduced lipid peroxidation induced by ISO (ISO vs. ISO + BOL; P < 0.05), and this effect was associated with increased superoxide dismutase (SOD) (ISO vs. ISO + BOL; P < 0.05) and glutathione-S-transferase levels (GST) (ISO vs. ISO + BOL; P < 0.05). This data suggest that BOL may improve cardiac oxidative stress and attenuate some parameters of adverse cardiac remodelling.
心脏中持续的肾上腺素能过载会导致适应性不良的心脏重塑，其中涉及氧化应激。波耳定碱（BOL）具有抗氧化活性，代表了一种新的治疗方法。本研究探讨了BOL在异丙肾上腺素诱导的不良左心室重塑中的心脏保护作用。将大鼠分为四组：对照组；BOL组（每日25mg/kg）；异丙肾上腺素（ISO）组（每日5mg/kg），以及ISO + BOL组。评估了形态学、超声心动图和氧化应激参数。BOL减轻了肾上腺素能过度刺激引起的心脏肥大和舒张期容积增加（P < 0.05）。BOL治疗降低了ISO诱导的脂质过氧化（ISO组与ISO + BOL组比较；P < 0.05），并且这种作用与超氧化物歧化酶（SOD）水平升高（ISO组与ISO + BOL组比较；P < 0.05）和谷胱甘肽-S-转移酶（GST）水平升高相关（ISO组与ISO + BOL组比较；P < 0.05）。这些数据表明，BOL可能改善心脏氧化应激并减轻不良心脏重塑的一些参数。
