Ji H, Jiang S, Sun C, Liu T, Yang G, Zhang L, Sun J, Wu J
Department of Nuclear Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, 210002, China.
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2025 May-Jun;44(3):500087. doi: 10.1016/j.remnie.2024.500087. Epub 2024 Dec 20.
The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).
88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUV of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.
There was a negative correlation between the SUV and quantitative classification value (r = -0.638, P < 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid predominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUV, and quantitative classification value (F = 3.849, P = 0.019; F = 27.420, P < 0.001; F = 4.353, P = 0.002). There were significant differences in GGO lesion size, SUV, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (F = 5.626, P = 0.011; F = 37.587, P < 0.001; F = 5.119, P = 0.008).
GGO lesion size, SUV, and quantitative classification value are correlated with different pathological subtypes and can be used toevaluate the prognosis of lung adenocarcinoma with GGO.
本研究旨在分析[18F]-FDG PET/CT（正电子发射断层扫描/计算机断层扫描）检查结果与伴有磨玻璃影（GGO）的肺腺癌病理亚型之间的相关性。
本研究纳入88例接受[18F]-FDG PET/CT检查并最终确诊为肺腺癌的患者。共分析90个GGO病灶。测量所有病灶的大小和SUV值，计算病灶中GGO实性成分的比例，并进行定量分类。根据2011年国际肺癌研究协会（IASLC）/美国胸科学会（ATS）/欧洲呼吸学会（ERS）肺腺癌病理分类，将上述GGO病灶分为预后良好组、预后相对良好组和预后不良组。采用卡方检验、独立样本t检验和方差分析进行统计学分析。
SUV值与定量分类值呈负相关（r = -0.638，P < 0.001）。非典型腺瘤样增生（AAH）、腺泡为主型腺癌（APA）、贴壁为主型腺癌（LPA）、乳头为主型腺癌（PPA）和实体为主型腺癌（SPA）在GGO病灶大小、SUV值和定量分类值方面存在显著差异（F = 3.849，P = 0.019；F = 27.420，P < 0.001；F = 4.353，P = 0.002）。预后良好组、预后相对良好组和预后不良组在GGO病灶大小、SUV值和定量分类值方面存在显著差异（F = 5.626，P = 0.011；F = 37.587，P < 0.001；F = 5.119，P = 0.008）。
GGO病灶大小、SUV值和定量分类值与不同病理亚型相关，可用于评估伴有GGO的肺腺癌的预后。
