Wira C R, Sullivan D A
Biol Reprod. 1985 Feb;32(1):90-5. doi: 10.1095/biolreprod32.1.90.
The present study examined the influence of hormones on the levels of immunoglobulins A (IgA) and G (IgG) and secretory component (SC) in cervicovaginal secretions of ovariectomized rats. Administration of estradiol to ovariectomized rats resulted in a significant decline in cervicovaginal content of IgA, IgG and SC. This response was dose dependent and was not prevented by administration of dexamethasone, a potent synthetic glucocorticoid, with estradiol. Treatment of ovariectomized rats with progesterone also lowered the levels of IgA and SC in cervicovaginal secretions. In contrast, dexamethasone had no apparent vaginal effect. The action of estradiol on cervicovaginal IgA, IgG and SC appears to be independent of uterine influence. This conclusion is based upon our observation that estrogen treatment of rats with ligations at their uterocervical junction still have decreased cervicovaginal IgA and SC levels. In parallel with this inhibitory effect, estradiol administration stimulated the accumulation of IgA and SC in uterine secretions. These findings indicate that the sex hormones play a role in regulating IgA, IgG and SC content in cervicovaginal secretions. In addition, it suggests that hormonal balance in females may influence the immune response of the reproductive tract to infectious disease.
本研究检测了激素对去卵巢大鼠宫颈阴道分泌物中免疫球蛋白A（IgA）、免疫球蛋白G（IgG）和分泌成分（SC）水平的影响。给去卵巢大鼠注射雌二醇导致宫颈阴道分泌物中IgA、IgG和SC的含量显著下降。这种反应呈剂量依赖性，并且与雌二醇同时注射强效合成糖皮质激素地塞米松并不能阻止这种下降。用孕酮处理去卵巢大鼠也会降低宫颈阴道分泌物中IgA和SC的水平。相比之下，地塞米松对阴道没有明显影响。雌二醇对宫颈阴道IgA、IgG和SC的作用似乎独立于子宫的影响。这一结论基于我们的观察，即对子宫颈交界处结扎的大鼠进行雌激素处理后，其宫颈阴道IgA和SC水平仍然下降。与这种抑制作用同时，注射雌二醇会刺激子宫分泌物中IgA和SC的积累。这些发现表明，性激素在调节宫颈阴道分泌物中IgA、IgG和SC的含量方面发挥作用。此外，这表明女性体内的激素平衡可能会影响生殖道对传染病的免疫反应。
