Yokota Sho, Taniguchi Toshibumi, Takayanagi Shin
Department of Infectious Diseases, Chiba University Hospital, Chiba, Japan.
Department of Infectious Diseases, Matsudo City General Hospital, Chiba, Japan.
J Infect Chemother. 2025 Mar;31(3):102595. doi: 10.1016/j.jiac.2024.102595. Epub 2024 Dec 20.
Brucella anthropi, an aerobic, glucose-nonfermenting gram-negative rod, is predominantly an opportunistic pathogen affecting immunosuppressed patients. This case report describes a 27-year-old woman with systemic lupus erythematosus who developed persistent B. anthropi bacteremia following a pregnancy termination. Despite her stable condition and minimal symptoms, including transient fever, blood cultures revealed persistent bacteremia. Initial treatment with ceftazidime was ineffective due to resistance, leading to a switch to ciprofloxacin, which ultimately resolved the bacteremia. This case underscores the challenges in identifying the source of infection in the absence of typical symptoms and highlights the importance of vigilance in monitoring for persistent bacteremia, even in clinically stable patients. Our findings suggest that symptom improvement does not guarantee the resolution of bacteremia, propose follow-up blood cultures to ensure effective management of B. anthropi bacteremia.
人布鲁氏菌是一种需氧、不发酵葡萄糖的革兰氏阴性杆菌，主要是一种影响免疫抑制患者的机会致病菌。本病例报告描述了一名27岁的系统性红斑狼疮女性，在终止妊娠后发生了持续性人布鲁氏菌菌血症。尽管她病情稳定且症状轻微，包括短暂发热，但血培养显示存在持续性菌血症。由于耐药，最初使用头孢他啶治疗无效，随后改用环丙沙星，最终解决了菌血症问题。该病例强调了在没有典型症状的情况下确定感染源的挑战，并突出了即使在临床稳定的患者中监测持续性菌血症的警惕性的重要性。我们的研究结果表明，症状改善并不保证菌血症的消退，建议进行后续血培养以确保有效管理人布鲁氏菌菌血症。
