Manoharan Ravi
Cell Signaling and Cancer Biology Laboratory, Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, India.
Drug Discov Today. 2025 Jan;30(1):104279. doi: 10.1016/j.drudis.2024.104279. Epub 2024 Dec 20.
Salt-inducible kinases (SIKs), a group of serine/threonine kinases in the adenosine monophosphate-activated protein kinase (AMPK) family, exist in three isoforms: SIK1, SIK2 and SIK3. These kinases are crucial in various physiological processes. Emerging evidence indicates that dysregulation of SIK expression and activation significantly contributes to carcinogenesis by promoting cellular proliferation, metabolic dysregulation, metastasis and chemoresistance through the modulation of crucial signaling pathways. The role of SIKs in cancer progression and metastasis involves complex mechanisms that vary among cancer types. Additionally, research on SIK inhibitors suggests that targeting these kinases might offer promising avenues for improving cancer treatment outcomes.
盐诱导激酶（SIKs）是腺苷单磷酸激活蛋白激酶（AMPK）家族中的一组丝氨酸/苏氨酸激酶，有三种同工型：SIK1、SIK2和SIK3。这些激酶在各种生理过程中起着关键作用。新出现的证据表明，SIK表达和激活的失调通过调节关键信号通路促进细胞增殖、代谢失调、转移和化疗耐药性，从而显著促进癌症发生。SIKs在癌症进展和转移中的作用涉及复杂的机制，这些机制因癌症类型而异。此外，对SIK抑制剂的研究表明，靶向这些激酶可能为改善癌症治疗结果提供有前景的途径。
