Mi Na, Zhang Shu-Ting, Sun Xiao-Li, Li Ting, Liao Yu, Dong Lei, Chu Ling-Ling
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
Department of Nursing, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
Brain Behav. 2024 Dec;14(12):e70197. doi: 10.1002/brb3.70197.
Adjuvant chemotherapy can promote the 5-year overall survival rate of pancreatic cancer (PC) patients to 16%-21%. However, the negative emotions of patients, such as anxiety, are usually omitted. Moreover, their disease burden concentrates on pain symptoms, seriously affecting the quality of life of patients. How to improve the negative emotions of PC patients, alleviate their pain, and ameliorate their quality of life has become an urgent issue.
To explore the effect of mindfulness meditation (MM) combined with the BrainLink intelligent biofeedback instrument on the anxiety, pain, brain fatigue, and quality of life of PC patients under chemotherapy.
A total of 145 PC patients under chemotherapy were admitted to the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Army Military Medical University from January 2022 to March 2024 and were incorporated as study objects. They were divided into a control group (n = 72) and a test group (n = 73) according to the random number table. The control group received routine nursing treatment; the experimental group was treated with MM combined with an intelligent biofeedback instrument. The general information, anxiety (SAS), pain (VAS), EEG signal data (degrees of fatigue, concentration, and relaxation and EEG waves), and quality of life (EORTC QLQ-C30) of the two groups before intervention and 4th, 8th, and 12th weeks after intervention were compared.
There is no significant difference in baseline data and pathological features between the two groups. After the 4th, 8th, and 12th weeks of intervention, the SAS values of the experimental group are remarkably lower than those of the control group (p < 0.05). In the 4th, 8th, and 12th weeks of intervention, the VAS scores of the experimental group are apparently lower than those of the control group (p < 0.05). In the 4th, 8th, and 12th weeks of intervention, the score of the quality of life (EORTC QLQ-C30) in the experimental group is significantly higher than that in the control group (p < 0.05). In the 4th, 8th, and 12th weeks, compared with the control group, the experimental group patients showed significant improvement in brain fatigue relief, concentration, and relaxation levels (p < 0.05), while the experimental group's brain α and θ. The wave showed an upward trend (p < 0.05).
MM combined with the BrainLink intelligent biofeedback instrument can significantly mitigate the anxiety, pain severity, and brain fatigue relief degree of PC patients under chemotherapy, thereby promoting their quality of life. It provides a novel intervention for the psychosomatic health of PC patients under chemotherapy.
辅助化疗可使胰腺癌（PC）患者的5年总生存率提高至16%-21%。然而，患者的焦虑等负面情绪通常被忽视。此外，他们的疾病负担集中在疼痛症状上，严重影响患者的生活质量。如何改善PC患者的负面情绪、减轻其疼痛并改善其生活质量已成为亟待解决的问题。
探讨正念冥想（MM）联合BrainLink智能生物反馈仪对化疗期间PC患者焦虑、疼痛、脑疲劳及生活质量的影响。
选取2022年1月至2024年3月在陆军军医大学第二附属医院肝胆外科住院化疗的145例PC患者作为研究对象。根据随机数字表将其分为对照组（n = 72）和试验组（n = 73）。对照组接受常规护理治疗；试验组采用MM联合智能生物反馈仪治疗。比较两组干预前及干预后第4、8、12周的一般资料、焦虑（SAS）、疼痛（VAS）、脑电信号数据（疲劳度、注意力、放松度及脑电波）及生活质量（EORTC QLQ-C30）。
两组基线数据及病理特征无显著差异。干预第4、8、12周后，试验组SAS值显著低于对照组（p < 0.05）。干预第4、8、12周时，试验组VAS评分明显低于对照组（p < 0.05）。干预第4、8、12周时，试验组生活质量（EORTC QLQ-C30）评分显著高于对照组（p < 0.05）。在第4、8、12周时，与对照组相比，试验组患者脑疲劳缓解、注意力及放松水平有显著改善（p < 0.05），而试验组脑α波和θ波呈上升趋势（p < 0.05）。
MM联合BrainLink智能生物反馈仪可显著减轻化疗期间PC患者的焦虑、疼痛严重程度及脑疲劳缓解程度，从而提高其生活质量。为化疗期间PC患者的身心健康提供了一种新的干预方法。
