阿拉伯人群中rs2200733单核苷酸多态性与心房颤动的关联：一项来自约旦的研究。
The Association Between the rs2200733 SNP and Atrial Fibrillation Among Arabs: A Study from Jordan.
作者信息
Al-Kasasbeh Abdullah H, Khabour Omar F, Almomani Rowida, Ababneh Muhannad, Ibdah Rashid, Jarrah Mohamad Ismail, Rawashdeh Sukaina I, Seif Abdelsamea Mohammed
机构信息
Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Biologics. 2024 Dec 17;18:389-395. doi: 10.2147/BTT.S490891. eCollection 2024.
INTRODUCTION
Atrial fibrillation (AFib) is a common disorder featured by an irregular and fast heartbeat. The etiology of AFib is complex and involves genetic and environmental factors. The rs2200733 single nucleotide polymorphism (SNP) is located in close proximity to the promoter of paired-like homeodomain transcription factor 2 (PITX2) which plays a role in heart development.
OBJECTIVE
In this study, the association between the rs2200733 SNP and AFib was examined in the Jordanian population.
METHODS
The study included 450 subjects (274 controls and 176 patients with AFib). Patients were recruited from King Abdullah University Hospital based on the European Society of Cardiology criteria. The rs2200733 SNP was genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique.
RESULTS
The mutant T allele of the rs2200733 SNP was common in the studied population with a frequency of 19%. The T allele and CT/TT genotypes were prevalent among patients with AFib compared with the controls (P<0.05, OR [CI]: 1.65 [1.12-2.43]). In addition, body mass index, diabetes, and hypertension were found to be associated with AFib risk.
CONCLUSION
The rs2200733 SNP was associated with AFib among Jordanian patients. The mutant T allele of the rs2200733 SNP might increase the risk of AFib.
引言
心房颤动（房颤）是一种以心跳不规则且快速为特征的常见病症。房颤的病因复杂，涉及遗传和环境因素。rs2200733单核苷酸多态性（SNP）位于成对样同源域转录因子2（PITX2）启动子附近，PITX2在心脏发育中起作用。
目的
本研究在约旦人群中检测rs2200733 SNP与房颤之间的关联。
方法
该研究纳入450名受试者（274名对照者和176名房颤患者）。根据欧洲心脏病学会标准，从阿卜杜拉国王大学医院招募患者。使用限制性片段长度多态性-聚合酶链反应（RFLP-PCR）技术对rs2200733 SNP进行基因分型。
结果
rs2200733 SNP的突变T等位基因在研究人群中常见，频率为19%。与对照组相比，T等位基因以及CT/TT基因型在房颤患者中更为普遍（P<0.05，比值比[置信区间]：1.65[1.12 - 2.43]）。此外，发现体重指数、糖尿病和高血压与房颤风险相关。
结论
在约旦患者中，rs2200733 SNP与房颤相关。rs2200733 SNP的突变T等位基因可能会增加房颤风险。
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