肉毒杆菌毒素对先天性寨卡综合征患儿肌张力和关节活动度的影响——病例系列
Botulinum Toxin's Effects on Muscle Tone and Joint Mobility in Children with Congenital Zika Syndrome - A Case Series.
作者信息
Silva Patrícia Juliana da, Brito Ana Stela Salvino de, Silva Mariana Balbino da, Barros Nathalia Nogueira Romariz, Tavares Jousilene Sales, Gama Gabriela Lopes
机构信息
Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, PB, Brasil.
Universidade Federal de Juiz de Fora (UFJF), Governador Valadares, MG, Brasil.
出版信息
Rev Bras Ortop (Sao Paulo). 2024 Dec 21;59(6):e936-e943. doi: 10.1055/s-0044-1792114. eCollection 2024 Dec.
To evaluate the effects of the botulinum toxin (BTX-A) on muscle tone and joint mobility in children with congenital Zika syndrome (CZS). This was a longitudinal case series carried out in a Support Center for Children with Microcephaly, located in Northeastern Brazil. We collected data from the institution's medical records, containing information about muscle tone and passive joint mobility measured at least 3 months before and 4 weeks after BTX-A application. We evaluated 13 children (9 boys) with a mean age of 77 ± 7.1 months. After BTX-A application, a bilateral reduction in the hypertonia level was observed in the elbow flexor ( < 0.01) and hip abductor ( < 0.05) muscles. No changes were observed in joint mobility and no adverse effects were reported by caregivers after application. The use of BTX-A can reduce hypertonia in CZS children, with no impact on joint mobility.
评估肉毒杆菌毒素（BTX-A）对先天性寨卡综合征（CZS）患儿肌张力和关节活动度的影响。 这是一项在巴西东北部一家小头畸形儿童支持中心开展的纵向病例系列研究。我们从该机构的病历中收集数据，其中包含在应用BTX-A前至少3个月以及应用后4周测量的肌张力和被动关节活动度信息。 我们评估了13名儿童（9名男孩），平均年龄为77±7.1个月。应用BTX-A后，观察到肘屈肌（<0.01）和髋外展肌（<0.05）的张力亢进水平双侧降低。 关节活动度未观察到变化，应用后护理人员未报告不良反应。BTX-A的使用可降低CZS患儿的肌张力亢进，且对关节活动度无影响。
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