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使用磁共振波谱代谢组学分析膝关节骨关节炎患者的滑液代谢谱

Analysis of Synovial Fluid Metabolic Profile in Patients with Knee Osteoarthritis Using Spectroscopic Magnetic Resonance Metabolomics.

作者信息

Alves Paulo Ricardo Picon, Aguiar Diego Pinheiro, Ladeira Aline Cordeiro Fernandes, Santos Gilson Costa Dos, Sousa Eduardo Branco de

机构信息

Divisão de Ensino e Pesquisa, Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad, Rio de Janeiro, RJ, Brasil.

Departamento de Farmácia, Faculdade de Ciências Biológicas e Saúde, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2024 Dec 21;59(6):e958-e965. doi: 10.1055/s-0044-1790217. eCollection 2024 Dec.

DOI:10.1055/s-0044-1790217
PMID:39711625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11663051/
Abstract

The present study aimed to evaluate the metabolic profile of synovial fluid in patients with knee osteoarthritis (KOA) and its correlation with clinical data.  We collected synovial fluid samples from the knees of 50 subjects with KOA undergoing total knee arthroplasty from October 2019 to December 2020. For each patient, we evaluated the clinical data from the medical record, the radiographic osteoarthritis grade, and the preoperative fasting blood glucose levels. The samples underwent metabolomic analysis by 1H magnetic resonance spectroscopy, and we compared the spectra using multivariate and univariate analyses.  Most patients were female (66%). The subjects had an average age of 67.96 ± 7.08 years old and an average body mass index (BMI) of 32.51 ± 5.25 kg/m . Clinical and metabolic evaluations revealed that 88% of patients were hypertensive and presented higher levels of valine, arginine, and citrate than non-hypertensive subjects. Metabolomic analysis of synovial fluid cannot classify osteoarthritis patients per their clinical characteristics.

摘要

本研究旨在评估膝骨关节炎（KOA）患者滑液的代谢谱及其与临床数据的相关性。

我们收集了2019年10月至2020年12月期间50例接受全膝关节置换术的KOA患者膝关节的滑液样本。对于每位患者，我们评估了病历中的临床数据、影像学骨关节炎分级和术前空腹血糖水平。样本通过1H磁共振波谱进行代谢组学分析，我们使用多变量和单变量分析比较光谱。

大多数患者为女性（66%）。受试者的平均年龄为67.96±7.08岁，平均体重指数（BMI）为32.51±5.25kg/m²。临床和代谢评估显示，88%的患者患有高血压，缬氨酸、精氨酸和柠檬酸盐水平高于非高血压患者。滑液的代谢组学分析无法根据骨关节炎患者的临床特征对其进行分类。

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本文引用的文献

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Metabolic phenotypes reflect patient sex and injury status: A cross-sectional analysis of human synovial fluid.
代谢表型反映了患者的性别和损伤状况：对人滑膜液的横断面分析。
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