Xue Youfeng, Shi Baojie, Zhong Jianfa, Wang Guimei, Wang Jie, An Wenbin, Qian Yunyun, Su Zhaojie, Peng Zhihai, Li Hao
Hepatobiliary Surgery Department, Fuqing Hospital, Fuzhou, Fujian, China.
Organ Transplantation Clinical Medical Center of Xiamen University, Department of Organ Transplantation, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Front Oncol. 2024 Dec 6;14:1495517. doi: 10.3389/fonc.2024.1495517. eCollection 2024.
A 13-year-old boy was admitted to Xiang'an Hospital of Xiamen University due to HBV-related liver cancer. Intrahepatic metastasis was considered to occur by CT scan. A gastroscope revealed esophagogastric variceal bleeding, and later, the patient underwent a successful liver transplantation. Fourteen months posttransplant, chest CT indicated lung metastasis, and the patient underwent thoracoscopic radical resection of lung cancer. Twenty-one months posttransplant, gastroscopy revealed a gastric fundus tumor growing into the gastric cavity. Proximal gastrectomy was performed, and pathology indicated moderately to poorly differentiated carcinoma without invasion of serosa, suggesting the first study to report HCC metastasis to the stomach lumen without invasion of serosa after LT. Currently, the alpha-fetoprotein (AFP) level of the patient has dropped below normal.
一名13岁男孩因乙肝相关肝癌入住厦门大学附属翔安医院。CT扫描考虑发生肝内转移。胃镜检查发现食管胃静脉曲张出血,随后患者成功接受了肝移植。移植后14个月,胸部CT显示肺转移,患者接受了胸腔镜下肺癌根治性切除术。移植后21个月,胃镜检查发现胃底肿瘤向胃腔内生长。进行了近端胃切除术,病理显示为中低分化癌,未侵犯浆膜,提示这是首例报道肝移植后肝癌转移至胃腔且未侵犯浆膜的研究。目前,患者的甲胎蛋白(AFP)水平已降至正常以下。