Liu Xinyan, Li Keou, Huang Tingxuan, Tang Hongfeng
Department of Dermatology, Shunde Hospital, The First People's Hospital of Shunde, Southern Medical University, Foshan, China.
Front Med (Lausanne). 2024 Dec 6;11:1514275. doi: 10.3389/fmed.2024.1514275. eCollection 2024.
Individuals with psoriasis face significant physiological and psychological burdens, and their compliance and satisfaction with medication regimens are alarmingly low. In recent years, the comorbidity of psoriasis has become a research focus. This study aims to explore the potential correlation between psoriasis and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR).
Data from 17,941 participants of the National Health and Nutrition Examination Survey (NHANES) spanning two intervals, 2003-2006 and 2009-2014, served as the foundation for this analysis. We used weighted logistic regression, stratified analysis, and restricted cubic spline (RCS) curve fitting to validate potential associations between NHHR and psoriasis risk.
In this investigation, the analysis of three different models highlighted elevated levels of the NHHR as a consistent risk factor for psoriasis. After adjusting for potential confounders, a positive correlation was observed between NHHR and the prevalence of psoriasis (OR = 1.08, 95% CI: 1.01, 1.15, < 0.05). Subgroup analysis and interaction tests were conducted to determine if variables such as age, gender, race/ethnicity, education level, smoking status, alcohol consumption, diabetes, coronary heart disease, and stroke impact the association between NHHR and psoriasis. The findings indicated no significant modification of the NHHR-psoriasis link by these factors, as all interaction -values were above 0.05. The RCS analysis uncovered a nonlinear relationship between psoriasis and the NHHR ( = 0.0176).
Statistical analysis confirms a significant correlation between the NHHR and the development of psoriasis, suggesting that NHHR may serve as a novel marker for predicting psoriasis risk. This correlation also provides insights for early health management strategies.
银屑病患者面临着巨大的生理和心理负担，而且他们对药物治疗方案的依从性和满意度低得惊人。近年来，银屑病的合并症已成为研究热点。本研究旨在探讨银屑病与非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）之间的潜在关联。
来自2003 - 2006年和2009 - 2014年两个时间段的17941名国家健康与营养检查调查（NHANES）参与者的数据作为本分析的基础。我们使用加权逻辑回归、分层分析和受限立方样条（RCS）曲线拟合来验证NHHR与银屑病风险之间的潜在关联。
在本次调查中，对三种不同模型的分析均突出显示NHHR水平升高是银屑病的一个一致风险因素。在调整潜在混杂因素后，观察到NHHR与银屑病患病率之间存在正相关（OR = 1.08，95% CI：1.01，1.15，P < 0.05）。进行亚组分析和交互检验以确定年龄、性别、种族/民族、教育水平、吸烟状况、饮酒量、糖尿病、冠心病和中风等变量是否会影响NHHR与银屑病之间的关联。结果表明这些因素并未对NHHR与银屑病的关联产生显著影响，因为所有交互P值均高于0.05。RCS分析揭示了银屑病与NHHR之间存在非线性关系（P = 0.0176）。
统计分析证实NHHR与银屑病的发生之间存在显著相关性，表明NHHR可能作为预测银屑病风险的一个新标志物。这种相关性也为早期健康管理策略提供了思路。
