亚甲基四氢叶酸还原酶基因rs1801133多态性与控制营养状况（CONUT）评分与结直肠癌易感性的关联
Association of Methylenetetrahydrofolate Reductase Gene rs1801133 Polymorphism and Controlling Nutritional Status (CONUT) Score with Colorectal Cancer Susceptibility.
作者信息
Zhang Zhuoxin, Wu Zuguang, Zeng Yuwen, Li Yunlin, Feng Yingchuan, Gao Zhen, Chen Yijin
机构信息
Department of Gastrointestinal Surgery, Meizhou People's Hospital, Meizhou, People's Republic of China.
Department of Gastroenterology, Meizhou People's Hospital, Meizhou, People's Republic of China.
出版信息
Int J Gen Med. 2024 Dec 17;17:6281-6290. doi: 10.2147/IJGM.S495139. eCollection 2024.
BACKGROUND
Susceptibility to some cancers is linked to methylenetetrahydrofolate reductase () polymorphisms and the Controlling Nutritional Status (CONUT) score in some populations. However, their relationship with susceptibility to colorectal cancer (CRC) susceptibility in the Hakka Chinese population remains unclear.
METHODS
In total, 620 CRC patients and 734 controls were enrolled. rs1801133 was genotyped, medical records (age, sex, smoking history, alcohol consumption, hypertension, diabetes mellitus, and family history of cancer, and blood cell parameters) were collected, and the relationship between this information and CRC susceptibility was analyzed.
RESULTS
There were significant differences in the distribution of CONUT classification (0.002), and proportions of history of smoking (0.001), hypertension (0.001), diabetes mellitus (0.001), and family history of cancer (0.002) between patients and controls. There were statistically significant differences in rs1801133 genotypes distribution (58.7% C/C, 35.5% C/T, and 5.8% T/T in patients vs 65.5%, 31.2%, and 3.3% in controls, =0.010) and allele distribution (76.5% C, and 23.5% T allele in patients vs 81.1%, and 18.9% in controls, =0.003) between patients and controls. Logistic regression analysis indicated that non-normal CONUT range (non-normal vs normal, odds ratio (OR): 1.451, 95% confidence interval (CI): 1.119-1.882, =0.005), and rs1801133 variant (C/T + T/T vs C/C, OR: 1.373, 95% CI: 1.091-1.728, =0.007), older age (≥65 vs <65 years, OR: 1.298, 95% CI: 1.023-1.646, =0.032), male sex (OR: 1.354, 95% CI: 1.067-1.718, =0.013), and history of alcohol drinking (OR: 2.232, 95% CI: 1.164-4.282, =0.016) were independently associated with CRC risk.
CONCLUSION
Individuals carried rs1801133 variant and with non-normal CONUT range, advanced age, history of alcohol consumption may be at increased CRC risk in the Hakka population.
背景
在某些人群中，某些癌症的易感性与亚甲基四氢叶酸还原酶（）多态性及控制营养状况（CONUT）评分有关。然而，它们与中国客家人群结直肠癌（CRC）易感性的关系仍不清楚。
方法
共纳入620例CRC患者和734例对照。对rs1801133进行基因分型，收集病历（年龄、性别、吸烟史、饮酒情况、高血压、糖尿病、癌症家族史及血细胞参数），并分析这些信息与CRC易感性之间的关系。
结果
患者与对照在CONUT分类分布（0.002）、吸烟史比例（0.001）、高血压比例（0.001）、糖尿病比例（0.001）及癌症家族史比例（0.002）方面存在显著差异。患者与对照在rs1801133基因型分布（患者中C/C为58.7%、C/T为35.5%、T/T为5.8%，对照中分别为65.5%、31.2%、3.3%，=0.010）及等位基因分布（患者中C等位基因为76.5%、T等位基因为23.5%，对照中分别为81.1%、18.9%，=0.003）方面存在统计学显著差异。逻辑回归分析表明，CONUT范围异常（异常vs正常，比值比（OR）：1.
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