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2
Efficacy and safety of tirzepatide, GLP-1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta-analysis.替尔泊肽、GLP-1受体激动剂及其他减肥药物在超重和肥胖症中的疗效与安全性：一项网状Meta分析
Obesity (Silver Spring). 2024 May;32(5):840-856. doi: 10.1002/oby.24002. Epub 2024 Feb 27.
3
The Road towards Triple Agonists: Glucagon-Like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Glucagon Receptor - An Update.通向三重激动剂的道路：胰高血糖素样肽 1、葡萄糖依赖性胰岛素释放肽和胰高血糖素受体——更新。
Endocrinol Metab (Seoul). 2024 Feb;39(1):12-22. doi: 10.3803/EnM.2024.1942. Epub 2024 Feb 14.
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Efficacy and safety of once weekly semaglutide 2·4 mg for weight management in a predominantly east Asian population with overweight or obesity (STEP 7): a double-blind, multicentre, randomised controlled trial.每周一次司美格鲁肽 2.4mg 用于超重或肥胖的主要为东亚人群的体重管理的疗效和安全性（STEP 7）：一项双盲、多中心、随机对照试验。
Lancet Diabetes Endocrinol. 2024 Mar;12(3):184-195. doi: 10.1016/S2213-8587(23)00388-1. Epub 2024 Feb 5.
5
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新旧抗肥胖药物。

Old and new anti-obesity drugs.

作者信息

Dodangeh Salimeh, Hasani-Ranjbar Shirin

机构信息

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Diabetes Metab Disord. 2024 Dec 19;24(1):16. doi: 10.1007/s40200-024-01512-5. eCollection 2025 Jun.

DOI:10.1007/s40200-024-01512-5
PMID:39712336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11659566/
Abstract

Obesity is a pandemic problem that correlates with a cluster of metabolic factors leading to poor cardiovascular outcomes, morbidity, and an increased risk of overall mortality. It is necessary to approach obesity with a comprehensive treatment plan, which may involve lifestyle modifications (diet, exercise, and behavioral therapy) and pharmacological interventions. This article provides an overview of the mechanisms of action, efficacy, and safety of available long-term anti-obesity drugs and introduces other potential agents under investigation.

摘要

肥胖是一个全球性的问题，它与一系列代谢因素相关，这些因素会导致不良的心血管结局、发病率以及总体死亡风险增加。采用全面的治疗方案来应对肥胖是必要的，这可能包括生活方式的改变（饮食、运动和行为疗法）以及药物干预。本文概述了现有长期抗肥胖药物的作用机制、疗效和安全性，并介绍了其他正在研究的潜在药物。