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一例采用药物治疗及置入丹佛分流管的难治性右颈纵隔淋巴管瘤

A refractory right cervical mediastinal lymphangioma with medication and insertion of a Denver shunt.

作者信息

Tatekawa Yukihiro, Tsuzuki Yukihiro, Fukuzato Yoshimitsu

机构信息

Department of Pediatric Surgery, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, 118-1 Arakawa, Haebaru-cho, Shimajiri-gun, Okinawa 901-1193, Japan.

出版信息

J Surg Case Rep. 2024 Dec 19;2024(12):rjae799. doi: 10.1093/jscr/rjae799. eCollection 2024 Dec.

DOI:10.1093/jscr/rjae799
PMID:39713059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11660929/
Abstract

The Denver shunt is used for persistent chylothorax as a pleuroperitoneal shunt. Insertion of a Denver shunt was attempted in the current case involving a 3-year-old male with a refractory right cervical mediastinal lymphangioma. He was medicated with Eppikajutsuto® (0.65 g/kg) and underwent a Denver shunt for volume reduction of the cervical cyst to prevent airway obstruction. However, revision surgery for hemorrhage in the lymphangioma revealed that the tip of the shunt catheter had penetrated the cyst wall. The rounded tip of the catheter was placed back into the cyst. Oral administration of sirolimus (1 mg) was added. The Denver shunt was removed due to a catheter infection and administration of sirolimus was temporarily stopped because of an elevated blood concentration. Six months postoperatively from the third operation, neck swelling was negligible and radiologic findings showed complete regression of the lymphangioma.

摘要

丹佛分流管作为一种胸膜腹膜分流装置,用于治疗持续性乳糜胸。在当前这个病例中,一名3岁男性患有难治性右颈纵隔淋巴管瘤,尝试插入丹佛分流管。给他服用了“エッピカジュツト”(0.65克/千克),并接受了丹佛分流术以减少颈部囊肿的体积,防止气道阻塞。然而,淋巴管瘤出血的翻修手术显示分流导管尖端穿透了囊肿壁。将导管的圆形尖端放回囊肿内。加用了西罗莫司(1毫克)口服。由于导管感染,移除了丹佛分流管,并且由于血液浓度升高,暂时停用了西罗莫司。第三次手术后六个月,颈部肿胀不明显,影像学检查结果显示淋巴管瘤完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/759f360159bc/rjae799f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/6c9aa3ffbc72/rjae799f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/7b3fea329bf5/rjae799f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/e2e8c5379022/rjae799f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/759f360159bc/rjae799f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/6c9aa3ffbc72/rjae799f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/70ef1375c5c5/rjae799f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/cf7503d0005a/rjae799f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/7b3fea329bf5/rjae799f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/e2e8c5379022/rjae799f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/911e/11660929/759f360159bc/rjae799f6.jpg

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本文引用的文献

1
Treatment of giant cervico-mediastinal lymphatic malformations: a case series.巨大型颈纵隔淋巴管瘤的治疗:病例系列
J Med Case Rep. 2018 Jun 15;12(1):167. doi: 10.1186/s13256-018-1705-0.
2
The use of sirolimus in the treatment of giant cystic lymphangioma: Four case reports and update of medical therapy.西罗莫司在巨大囊性淋巴管瘤治疗中的应用:4例病例报告及药物治疗进展
Medicine (Baltimore). 2017 Dec;96(51):e8871. doi: 10.1097/MD.0000000000008871.
3
Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study.
草药治疗小儿淋巴管畸形的临床疗效:一项试点研究。
Pediatr Dermatol. 2016 Mar-Apr;33(2):191-5. doi: 10.1111/pde.12777. Epub 2016 Jan 17.
4
Pleuroperitoneal shunt for chylothorax and chylopericardium in lung cancer: a case report.肺癌合并乳糜胸和乳糜心包的胸膜腹膜分流术:一例报告
Ann Thorac Cardiovasc Surg. 2011;17(1):63-6. doi: 10.5761/atcs.cr.09.01482.
5
A case of mediastinal lymphangioma successfully treated with Kampo medicine.经方治疗纵隔淋巴管瘤 1 例
J Altern Complement Med. 2011 Jun;17(6):563-5. doi: 10.1089/acm.2010.0562. Epub 2011 May 13.