Li Wan, Liu Jia, Li Changqing, Yang Hui, Yang Yating, Li Zhiwei, Yang Shouqiang, He Yuan, Xiao Guanglin, Wang Ya, Chen Yongjun
Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, China.
West China Second University Hospital, SCU, Chengdu, China.
PeerJ. 2024 Dec 19;12:e18589. doi: 10.7717/peerj.18589. eCollection 2024.
As a group of more than 3.67 million people, the bone health of Chinese plasmapheresis donors, which the main population is also a risk group of osteoporosis (OP), has raised concerns. Therefore, this article investigates the relationship between bone mineral density (BMD), bone metabolism indicators, and plasmapheresis donation behavior among some high-risk plasmapheresis donors for OP in China, and further explores the mediating factors through reasonable statistical methods.
Recruiting long-term and highly active plasmapheresis donors and new donors to measure the total calcium, albumin (ALB), 25-hydroxy vitamin D (25OHD), parathyroid hormone (PTH), type I procollagen amino-terminal peptide (P1NP), and type I collagen carboxy-terminal peptide (-CTX) and serum ferritin (SF). Then, multiple linear regression was used to adjust confounding factors. Using restrictive cubic splines to explore the nonlinear relationship. Using the Bootstrap method, investigate whether SF has a mediating effect between plasmapheresis donation behavior and bone metabolism biomakers. Finally, analyze the differences in BMD between the two.
Compared to new donors, repeat donors have a lower 25OHD, -CTX and SF levels, while P1NP and PTH levels are high, with statistical differences. The Bootstrap analysis results show that SF level is a partial mediating factor between plasmapheresis donation behavior and bone metabolism biomakers, with a mediating effect ratio of 21.8%. There was no significant difference in the BMD between the two.
Long-term and frequently plasmapheresis donation does not affect the bone mass of even elderly donors at high risk for osteoporosis under the existing collection standards and anticoagulant use in China. However, as a self-regulation way, it does increase the osteogenic activity of the body.
作为一个超过367万人的群体，中国单采血浆捐献者的骨骼健康引发了关注，其主要人群也是骨质疏松症（OP）的风险群体。因此，本文调查了中国部分OP高风险单采血浆捐献者的骨密度（BMD）、骨代谢指标与单采血浆捐献行为之间的关系，并通过合理的统计方法进一步探索中介因素。
招募长期且频繁单采血浆的捐献者和新捐献者，测量总钙、白蛋白（ALB）、25-羟基维生素D（25OHD）、甲状旁腺激素（PTH）、I型前胶原氨基端肽（P1NP）、I型胶原羧基端肽（-CTX）和血清铁蛋白（SF）。然后，采用多元线性回归调整混杂因素。使用限制性立方样条探索非线性关系。采用Bootstrap法，研究SF在单采血浆捐献行为与骨代谢生物标志物之间是否具有中介作用。最后，分析两者之间BMD的差异。
与新捐献者相比，重复捐献者的25OHD、-CTX和SF水平较低，而P1NP和PTH水平较高，差异有统计学意义。Bootstrap分析结果显示，SF水平是单采血浆捐献行为与骨代谢生物标志物之间的部分中介因素，中介效应比例为21.8%。两者之间的BMD无显著差异。
在中国现有的采集标准和抗凝剂使用情况下，长期频繁单采血浆捐献即使对骨质疏松高风险的老年捐献者的骨量也没有影响。然而，作为一种自我调节方式，它确实增加了身体的成骨活性。
