Deng Zhi-Hao, Li Xin, Liu Li, Zeng Hai-Min, Chen Bo-Fan, Peng Jie
The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
The First Clinical Medical College, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 310006, Jiangxi Province, China.
World J Gastroenterol. 2024 Dec 21;30(47):5097-5103. doi: 10.3748/wjg.v30.i47.5097.
A recent study published in the , suggests that transplanting the gut microbiota from healthy donors can alleviate the pathological processes linked to inflammatory bowel disease (IBD), particularly Crohn's disease. In addition, that paper illustrates the effect of changes in the gut microbiota on IBD and points out that altered mesenteric adipose tissue caused by the gut microbiota and creeping fat lead to increased inflammation, which exacerbates IBD. Moreover, recent research has shown that the interaction between () and the gut microbiota is mediated through immune mechanisms, resulting in a synergistic impact on IBD. Therefore, in this manuscript, we will focus on the role of the gut microbiota and in the immune response to IBD, as well as the possible impact of on the gut microbiota. We will also explore their individual and synergistic immune effects on IBD and look at future therapeutic perspectives for IBD.
最近发表在《 》上的一项研究表明，移植健康供体的肠道微生物群可以缓解与炎症性肠病（IBD）相关的病理过程，尤其是克罗恩病。此外，该论文阐述了肠道微生物群变化对IBD的影响，并指出由肠道微生物群和匐行脂肪引起的肠系膜脂肪组织改变会导致炎症增加，从而加剧IBD。此外，最近的研究表明，（ ）与肠道微生物群之间的相互作用是通过免疫机制介导的，对IBD产生协同影响。因此，在本手稿中，我们将重点关注肠道微生物群和（ ）在IBD免疫反应中的作用，以及（ ）对肠道微生物群的可能影响。我们还将探讨它们对IBD的个体和协同免疫作用，并展望IBD未来的治疗前景。
