Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Nutrients. 2023 Oct 21;15(20):4466. doi: 10.3390/nu15204466.
The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber. Certain microbes in the gut are responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance in gut microbiome diversity can lead to metabolic disorders and inflammation-related diseases. Changes in SCFA levels and associated microbiota were observed in IBD, suggesting an association between SCFAs and disease. The gut microbiota and SCFAs affect reactive oxygen species (ROS) associated with IBD. Gut microbes and SCFAs are closely related to IBD, and it is important to study them further.
肠道微生物组是人类胃肠道中多样化的细菌群落，在多种生物过程中发挥重要作用。短链脂肪酸（SCFA）是通过膳食纤维发酵产生的。肠道中的某些微生物负责产生 SCFAs，如乙酸盐、丙酸盐和丁酸盐。肠道微生物组多样性的失衡可导致代谢紊乱和炎症相关疾病。在 IBD 中观察到 SCFA 水平和相关微生物群的变化，提示 SCFAs 与疾病之间存在关联。肠道微生物群和 SCFAs 影响与 IBD 相关的活性氧（ROS）。肠道微生物和 SCFAs 与 IBD 密切相关，进一步研究它们很重要。
