• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

解码ATP合酶抑制因子1（ATPIF1）在沃勒变性和周围神经再生中的调节作用。

Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration.

作者信息

Qian Yun, Yan Zhiwen, Ye Tianbao, Shahin Victor, Jiang Jia, Fan Cunyi

机构信息

Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China.

Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration Shanghai People's Republic of China.

出版信息

Exploration (Beijing). 2024 Mar 19;4(6):20230098. doi: 10.1002/EXP.20230098. eCollection 2024 Dec.

DOI:10.1002/EXP.20230098
PMID:39713198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11655313/
Abstract

ATP synthase inhibitory factor 1 (ATPIF1), a key modulator of ATP synthase complex activity, has been implicated in various physiological and pathological processes. While its role is established in conditions such as hypoxia, ischemia-reperfusion injury, apoptosis, and cancer, its involvement remains elusive in peripheral nerve regeneration. Leveraging ATPIF1 knockout transgenic mice, this study reveals that the absence of ATPIF1 impedes neural structural reconstruction, leading to delayed sensory and functional recovery. RNA-sequencing unveils a significant attenuation in immune responses following peripheral nerve injury, which attributes to the CCR2/CCL2 signaling axis and results in decreased macrophage infiltration and activation. Importantly, macrophages, not Schwann cells, are identified as key contributors to the delayed Wallerian degeneration in ATPIF1 knockout mice, and affect the overall outcome of peripheral nerve regeneration. These results shed light on the translational potential of ATPIF1 for improving peripheral nerve regeneration.

摘要

ATP合酶抑制因子1（ATPIF1）是ATP合酶复合体活性的关键调节因子，已被证明参与多种生理和病理过程。虽然其在缺氧、缺血再灌注损伤、细胞凋亡和癌症等情况下的作用已得到证实，但其在周围神经再生中的作用仍不明确。本研究利用ATPIF1基因敲除转基因小鼠，发现ATPIF1的缺失会阻碍神经结构重建，导致感觉和功能恢复延迟。RNA测序显示，周围神经损伤后免疫反应显著减弱，这归因于CCR2/CCL2信号轴，导致巨噬细胞浸润和活化减少。重要的是，巨噬细胞而非施万细胞被确定为ATPIF1基因敲除小鼠中沃勒变性延迟的关键因素，并影响周围神经再生的总体结果。这些结果为ATPIF1在改善周围神经再生方面的转化潜力提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/daf6d9c312c4/EXP2-4-20230098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/2bc0c62a8a5a/EXP2-4-20230098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/56f3be137950/EXP2-4-20230098-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/c9879b26b764/EXP2-4-20230098-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/a61ca38f68cb/EXP2-4-20230098-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/9ffb0af4fe1b/EXP2-4-20230098-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/daf6d9c312c4/EXP2-4-20230098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/2bc0c62a8a5a/EXP2-4-20230098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/56f3be137950/EXP2-4-20230098-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/c9879b26b764/EXP2-4-20230098-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/a61ca38f68cb/EXP2-4-20230098-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/9ffb0af4fe1b/EXP2-4-20230098-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4cc/11655313/daf6d9c312c4/EXP2-4-20230098-g001.jpg

相似文献

1
Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration.解码ATP合酶抑制因子1（ATPIF1）在沃勒变性和周围神经再生中的调节作用。
Exploration (Beijing). 2024 Mar 19;4(6):20230098. doi: 10.1002/EXP.20230098. eCollection 2024 Dec.
2
Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.SIRPα（信号调节蛋白-α）缺失可促进 Wallerian 变性、轴突再生和神经损伤恢复过程中髓鞘碎片的吞噬清除。
J Neuroinflammation. 2019 Dec 28;16(1):277. doi: 10.1186/s12974-019-1679-x.
3
The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration.主要的巨噬细胞趋化因子 CCL2 在周围神经损伤后对于巨噬细胞募集和激活或条件性损伤增强外周再生并非必需。
J Neuroinflammation. 2022 Jul 12;19(1):179. doi: 10.1186/s12974-022-02497-9.
4
Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice.小鼠周围神经损伤后巨噬细胞特异性 RhoA 敲除延迟 Wallerian 变性。
J Neuroinflammation. 2021 Oct 15;18(1):234. doi: 10.1186/s12974-021-02292-y.
5
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury.巨噬细胞在外周神经损伤后的 Wallerian 变性和轴突再生中的作用。
Acta Neuropathol. 2015 Nov;130(5):605-18. doi: 10.1007/s00401-015-1482-4. Epub 2015 Sep 29.
6
Neither injury induced macrophages within the nerve, nor the environment created by Wallerian degeneration is necessary for enhanced in vivo axon regeneration after peripheral nerve injury.无论是神经内的损伤诱导的巨噬细胞，还是 Wallerian 变性所产生的环境，对于外周神经损伤后体内轴突再生的增强都不是必需的。
J Neuroinflammation. 2024 May 27;21(1):134. doi: 10.1186/s12974-024-03132-5.
7
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury.Toll样受体3参与周围神经损伤后的沃勒变性。
Neuroimmunomodulation. 2016;23(4):209-216. doi: 10.1159/000449134. Epub 2016 Oct 22.
8
Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration.米诺环素可保护雪旺细胞免受缺血样损伤，并促进缺乏华勒变性的生物人工神经移植物中的轴突生长。
Exp Neurol. 2008 Jul;212(1):189-200. doi: 10.1016/j.expneurol.2008.03.028. Epub 2008 Apr 15.
9
Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration.在沃勒变性的周围神经损伤模型中，中性粒细胞对髓鞘清除至关重要。
J Neurosci. 2017 Oct 25;37(43):10258-10277. doi: 10.1523/JNEUROSCI.2085-17.2017. Epub 2017 Sep 14.
10
CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype.CD300f免疫受体通过调节巨噬细胞炎症表型促进周围神经再生。
J Neuroinflammation. 2015 Aug 12;12:145. doi: 10.1186/s12974-015-0364-y.

引用本文的文献

1
Advanced development of conductive biomaterials for enhanced peripheral nerve regeneration: a review.用于增强周围神经再生的导电生物材料的研究进展：综述
RSC Adv. 2025 Apr 22;15(17):12997-13009. doi: 10.1039/d5ra01107h.
2
Reduce electrical overload via threaded Chinese acupuncture in nerve electrical therapy.在神经电疗法中通过螺纹式中医针灸减少电过载。
Bioact Mater. 2025 Jan 3;46:476-493. doi: 10.1016/j.bioactmat.2024.12.025. eCollection 2025 Apr.

本文引用的文献

1
Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults.老年人身体活动水平与 ATP 酶抑制因子 1 浓度的相关性。
J Sport Health Sci. 2024 May;13(3):409-418. doi: 10.1016/j.jshs.2023.09.009. Epub 2023 Sep 23.
2
Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase.ATP 合酶中 ATP 酶抑制因子 1 被强制排出的分子机制。
Nat Commun. 2023 Mar 31;14(1):1682. doi: 10.1038/s41467-023-37182-9.
3
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
G 蛋白偶联受体 35 激动剂对线粒体重构和缺血保护的作用。
Science. 2022 Aug 5;377(6606):621-629. doi: 10.1126/science.abm1638. Epub 2022 Aug 4.
4
The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function.ATP酶抑制因子1是线粒体ATP合酶结构与功能的组织特异性生理调节因子：深入探究神经元功能
Front Physiol. 2022 Mar 18;13:868820. doi: 10.3389/fphys.2022.868820. eCollection 2022.
5
Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts.线粒体 ATP 酶抑制因子 1（ATPIF1）的上调介导了小鼠心脏中糖酵解的增加。
J Clin Invest. 2022 May 16;132(10). doi: 10.1172/JCI155333.
6
Neuroprotective effects of ATPase inhibitory factor 1 preventing mitochondrial dysfunction in Parkinson's disease.ATP 酶抑制因子 1 防止帕金森病中线粒体功能障碍的神经保护作用。
Sci Rep. 2022 Mar 9;12(1):3874. doi: 10.1038/s41598-022-07851-8.
7
ATPase inhibitory factor 1 protects the heart from acute myocardial ischemia/reperfusion injury through activating AMPK signaling pathway.三磷酸腺苷酶抑制因子 1 通过激活 AMPK 信号通路保护心脏免受急性心肌缺血/再灌注损伤。
Int J Biol Sci. 2022 Jan 1;18(2):731-741. doi: 10.7150/ijbs.64956. eCollection 2022.
8
Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms.用于周围神经工程的二维纳米材料：最新进展与潜在机制
Front Bioeng Biotechnol. 2021 Nov 8;9:746074. doi: 10.3389/fbioe.2021.746074. eCollection 2021.
9
Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?靶向 CCL2/CCR2 轴在癌症免疫治疗中的应用：一石三鸟？
Front Immunol. 2021 Nov 3;12:771210. doi: 10.3389/fimmu.2021.771210. eCollection 2021.
10
The Multifaceted ATPase Inhibitory Factor 1 (IF1) in Energy Metabolism Reprogramming and Mitochondrial Dysfunction: A New Player in Age-Associated Disorders?多功能 ATP 酶抑制因子 1（IF1）在能量代谢重编程和线粒体功能障碍中的作用：与年龄相关疾病相关的新角色？
Antioxid Redox Signal. 2022 Aug;37(4-6):370-393. doi: 10.1089/ars.2021.0137. Epub 2022 Jan 4.