Omori Naoki, Ishida Manabu, Takamura Masahiro, Abe Satoshi, Nagai Atsushi
Department of Neurology, Shimane University, Izumo, Japan.
ERISA Corporation, Matsue, Japan.
Front Aging Neurosci. 2024 Dec 6;16:1444308. doi: 10.3389/fnagi.2024.1444308. eCollection 2024.
Anemia is a risk factor for dementia development. However, few studies have examined the relationship between brain volume and anemia. This study aimed to analyze the association between anemia and brain volume using magnetic resonance imaging data from brain health checkups.
Participants underwent brain health checkups between January 2015 and March 2022. Blood samples were collected to measure hemoglobin concentrations and mean corpuscular volumes. The modified Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. Magnetic resonance images were analyzed using voxel-based Morphometry to evaluate the overall patterns of brain volume. After extracting the principal components (PCs) from PC analysis, we investigated their association with MMSE scores and anemia.
This study included 1,029 participants and identified principal components, representing smaller volume in the frontal lobe (PC1), and smaller volume in the limbic system to the temporal lobe (PC2). A higher PC2 score was significantly associated with a lower MMSE score. Male participants with anemia had smaller bilateral PC1 volumes and left hippocampal volumes, and female participants with anemia had smaller bilateral PC2 volumes and hippocampus volumes.
PC2 may represent the extent of disease affecting limbic system volume, such as Alzheimer's disease. Our results suggest that anemia may be associated with smaller volumes in the limbic system, especially in women. Further studies are required to determine which type of anemia is more strongly correlated with smaller brain volumes.
贫血是痴呆症发展的一个风险因素。然而，很少有研究探讨脑容量与贫血之间的关系。本研究旨在利用脑部健康检查的磁共振成像数据，分析贫血与脑容量之间的关联。
参与者在2015年1月至2022年3月期间接受了脑部健康检查。采集血样以测量血红蛋白浓度和平均红细胞体积。采用改良简易精神状态检查表（MMSE）评估认知功能。利用基于体素的形态学测量方法分析磁共振图像，以评估脑容量的整体模式。从主成分分析中提取主成分（PCs）后，我们研究了它们与MMSE评分和贫血的关联。
本研究纳入了1029名参与者，并确定了主成分，分别代表额叶体积较小（PC1），以及从边缘系统到颞叶的体积较小（PC2）。PC2得分越高，与MMSE得分越低显著相关。贫血男性参与者的双侧PC1体积和左侧海马体积较小，贫血女性参与者的双侧PC2体积和海马体积较小。
PC2可能代表影响边缘系统体积的疾病程度，如阿尔茨海默病。我们的结果表明，贫血可能与边缘系统体积较小有关，尤其是在女性中。需要进一步研究以确定哪种类型的贫血与较小的脑容量相关性更强。
