Subasi Turgut Fatma, Karadag Mehmet, Taysi Seyithan, Hangül Zehra, Gokcen Cem
Kızıltepe Public Hospital, Kızıltepe, Turkey.
Gaziantep Universitesi Tip Fakultesi, Gaziantep, Turkey.
Int J Dev Disabil. 2023 Mar 20;70(8):1441-1451. doi: 10.1080/20473869.2023.2185959. eCollection 2024.
Recent studies show that oxidative stress has an important role in the etiology of autism. In our study, Nrf2, which is the main regulator of cellular antioxidant response, and Keap1 and Gsk-3β, which are the main proteins that regulate this pathway, were compared between children with autism and healthy controls. To the best of our knowledge, our study is the first in which Nrf2, Keap1 and Gsk-3β levels were evaluated together in children with ASD. In our study, Nrf2 level was found to be lower and Keap1 level higher in children with autism. Although GSK-3β is increased in many psychiatric and neurodegenerative diseases, it was found to be low in the autistic group in accordance with the literature. In conclusion, considering the versatile modulation of the Nrf2 pathway, this article does not provide any mechanistic insight into the pathway, but it suggests that Nrf2, Keap1 and Gsk-3β, which have central roles in oxidative stress, may play a role in the pathophysiology of autism.
最近的研究表明，氧化应激在自闭症的病因中起重要作用。在我们的研究中，比较了自闭症儿童和健康对照者之间作为细胞抗氧化反应主要调节因子的Nrf2，以及调节该途径的主要蛋白质Keap1和Gsk-3β。据我们所知，我们的研究是首次在自闭症谱系障碍（ASD）儿童中同时评估Nrf2、Keap1和Gsk-3β水平。在我们的研究中，发现自闭症儿童的Nrf2水平较低，Keap1水平较高。尽管GSK-3β在许多精神疾病和神经退行性疾病中升高，但根据文献，在自闭症组中发现其水平较低。总之，考虑到Nrf2途径的多种调节作用，本文未提供该途径的任何机制性见解，但表明在氧化应激中起核心作用的Nrf2、Keap1和Gsk-3β可能在自闭症的病理生理学中起作用。
