State Key Labobatory of Hulless and Yak Germplasm Resources and Genetic Improvement, Lhasa, Tibet, 850000, China.
Colleges of Life Science and Technology, Dalian University, Dalian Economic-Technological Development Zone, Liaoning, 116622, China; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510100, China.
Biomed Pharmacother. 2020 Jun;126:110074. doi: 10.1016/j.biopha.2020.110074. Epub 2020 Mar 9.
Cardiovascular disease (CVD) is a significant cause of death worldwide. Because of its major individual differences in genetic background, pathogenesis, and disease progression pattern, the mortality risk rate remains high following conventional Western medicine diagnosis under current guidelines. Traditional Chinese medicine (TCM) has important multi-target, multi-pathway, and multi-layer benefits that can effectively address western medicine deficiencies. It was therefore commonly used in CVD diagnosis. Oxidative stress is also one of the main factors of CVD. Likewise, this main reaction regulator is the nuclear factor erythroid-2-related (Nrf2) factor. When activated, it can be transferred to the nucleus and initiated in the downstream pathway, thus playing an anti-oxidant stress role. As one of the most crucial endogenous protection systems in the body, Nrf2-related / heme oxygenase 1 (Nrf2/HO-1) signaling pathway is Nrf2's most classic approach to playing roles. Recently, various advances have been made to research and explain TCM by manipulating this pathway to treat CVD using modern molecular biology and other approaches. This analysis summarized the relationship between Nrf2/HO-1 signaling route, CVD and TCM. Further, Autodock calculation was also conducted to determine the binding amino acid on this TCM to Nrf2 and HO-1.
心血管疾病（CVD）是全球范围内主要的死亡原因之一。由于其在遗传背景、发病机制和疾病进展模式方面存在重大个体差异，根据现行指南，在常规西医诊断下，死亡率仍然居高不下。中医药具有多靶点、多途径、多层次的重要优势，可有效弥补西医的不足，因此常用于 CVD 的诊断。氧化应激也是 CVD 的主要因素之一。同样，这个主要的反应调节因子是核因子红细胞 2 相关因子（Nrf2）。当被激活时，它可以转移到细胞核并启动下游途径，从而发挥抗氧化应激作用。作为体内最重要的内源性保护系统之一，Nrf2 相关/血红素加氧酶 1（Nrf2/HO-1）信号通路是 Nrf2 发挥作用的最经典途径。最近，通过使用现代分子生物学和其他方法来操纵该途径，用中医药治疗 CVD 的研究和解释方面取得了各种进展。本分析总结了 Nrf2/HO-1 信号通路、CVD 和中医药之间的关系。此外，还进行了 Autodock 计算以确定该中医药与 Nrf2 和 HO-1 的结合氨基酸。
