Kuwahara Yuta, Saji Mike, Yazaki Satoshi, Kishiki Kanako, Yoshikawa Tadahiro, Komori Yuya, Wada Naoki, Shimizu Jun, Isobe Mitsuaki
Department of Adult Congenital Heart Disease Center, Sakakibara Heart Institute, Tokyo, Japan.
Department of Pediatric Cardiovascular Surgery, Sakakibara Heart Institute, Tokyo, Japan.
Int J Cardiol Congenit Heart Dis. 2022 Oct 1;10:100421. doi: 10.1016/j.ijcchd.2022.100421. eCollection 2022 Dec.
As more patients with congenital heart disease survive into adulthood, the number of patients with tetralogy of Fallot (TOF) has also increased. However, long-term sequelae are common, and most patients with TOF require surgical reintervention in adulthood. Prolonged intensive care unit (ICU) stay is associated with poor long-term outcomes following cardiac surgery. This study aimed to investigate whether the PErioperative Adult Congenital Heart disease (PEACH) score can predict prolonged postoperative ICU stay in this population.
Of 1217 patients with congenital heart disease who were ≥18 years old at the time of surgery performed from February 2004 and August 2021, 145 consecutive patients with TOF who underwent right ventricular outflow tract procedures were examined in this single-institution retrospective study. The primary endpoint was ICU stay of ≥3 days.
The population had a history of one sternotomies (median) (1, 2; 1st and 3rd quartiles) at a median age of 35 years (25, 42; 1st and 3rd quartiles). The median duration of ICU stay was one day (1, 2; 1st and 3rd quartiles). Significantly more patients experienced major bleeding and ventilator dependence after surgery than those without prolonged ICU stay. Cardiopulmonary bypass time was significantly longer in patients with prolonged ICU stay than in those without. The PEACH score was independently associated with prolonged ICU stay after adjusted multivariate analyses and had acceptable discriminatory performance for predicting prolonged ICU stay after surgery.
The PEACH score is a useful predictor of prolonged postoperative ICU stay in this population.
随着越来越多的先天性心脏病患者存活至成年,法洛四联症(TOF)患者的数量也有所增加。然而,长期后遗症很常见,大多数TOF患者在成年期需要进行手术再次干预。心脏手术后在重症监护病房(ICU)停留时间延长与不良的长期预后相关。本研究旨在调查围手术期成人先天性心脏病(PEACH)评分是否能够预测该人群术后在ICU的延长停留时间。
在2004年2月至2021年8月期间接受手术时年龄≥18岁的1217例先天性心脏病患者中,本单机构回顾性研究检查了145例连续接受右心室流出道手术的TOF患者。主要终点是在ICU停留≥3天。
该人群有胸骨切开术史(中位数)(1,2;第1和第3四分位数),中位年龄为35岁(25,42;第1和第3四分位数)。ICU停留的中位持续时间为1天(1,2;第1和第3四分位数)。与未延长ICU停留时间的患者相比,术后发生大出血和呼吸机依赖的患者明显更多。延长ICU停留时间的患者体外循环时间明显长于未延长的患者。经过多变量调整分析后,PEACH评分与ICU停留时间延长独立相关,并且在预测术后ICU停留时间延长方面具有可接受的鉴别性能。
PEACH评分是该人群术后ICU停留时间延长的有用预测指标。