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长期重症监护后心脏手术患者的长期生存及功能能力

Long-term survival and functional capacity in cardiac surgery patients after prolonged intensive care.

作者信息

Bashour C A, Yared J P, Ryan T A, Rady M Y, Mascha E, Leventhal M J, Starr N J

机构信息

Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, OH 44195, USA.

出版信息

Crit Care Med. 2000 Dec;28(12):3847-53. doi: 10.1097/00003246-200012000-00018.

Abstract

OBJECTIVE

To determine whether hospital discharge alone represents a good outcome for patients who had prolonged intensive care after cardiac surgery by studying their postdischarge survival and functional outcome. The secondary objective is to estimate the proportion of intensive care unit (ICU) resources used by the long-stay (> or = 10 initial consecutive ICU days) patients and to identify preoperative patient characteristics that are associated with a prolonged ICU stay and hospital and long-term survival.

DESIGN

Inception cohort study.

SETTING

The Cleveland Clinic Foundation, a tertiary care, academic teaching institution.

PATIENTS

Cardiac surgery patients with an initial ICU stay of 10 or more consecutive days.

INTERVENTIONS

Data were collected daily during hospitalization on every adult who underwent coronary artery bypass graft and/or valve surgery at one institution in 1993. Discharged patients who spent >10 initial consecutive days in the ICU after surgery were contacted by telephone to determine vital status and functional capacity using the Duke Activity Status Index. Total ICU and total hospital direct costs were obtained for each patient.

MEASUREMENTS AND MAIN RESULTS

The primary outcome measurements were ICU length of stay, hospital mortality, after-surgery and postdischarge mortality and functional capacity, and relative resource utilization. Of the 2,618 cardiac surgery patients who met the inclusion criteria, 142 (5.4%) had an initial ICU length of stay of 10 or more consecutive days. Of these, 47 (33.1%) died in the hospital. Ninety-four of the 95 discharged patients were followed up (median follow-up, 30.6 months), and 44 of the 94 (46.8%) died during the follow-up period. The median Duke Activity Status Index for the 50 survivors was 26 out of a possible 58.2. The 142 long-stay patients used 50% of the total ICU days and 48% of the total ICU direct cost for all 2,618 patients.

CONCLUSIONS

Many survivors of prolonged intensive care die soon after hospital discharge and many longer term survivors have a poor functional state. Therefore, hospital discharge is an incomplete measure of outcome for these patients, and longer follow-up is more appropriate. The relatively small number of patients who require prolonged intensive care consumes a disproportionate amount of the total ICU and total hospital direct cost.

摘要

目的

通过研究心脏手术后长期重症监护患者出院后的生存情况和功能转归,确定仅出院是否就代表良好的预后。次要目的是估计长期住院(最初连续入住重症监护病房≥10天)患者所使用的重症监护病房(ICU)资源比例,并确定与ICU住院时间延长、住院及长期生存相关的术前患者特征。

设计

队列起始研究。

地点

克利夫兰诊所基金会,一家三级医疗学术教学机构。

患者

最初连续入住ICU达10天或更长时间的心脏手术患者。

干预措施

1993年在一家机构对每例接受冠状动脉搭桥术和/或瓣膜手术的成年患者住院期间每日收集数据。对术后在ICU最初连续住院>10天的出院患者进行电话随访,使用杜克活动状态指数确定其生命状态和功能能力。获取每位患者的ICU总费用和医院总直接费用。

测量指标和主要结果

主要结局测量指标为ICU住院时间、住院死亡率、术后及出院后死亡率和功能能力,以及相对资源利用情况。在符合纳入标准的2618例心脏手术患者中,142例(5.4%)最初连续入住ICU达10天或更长时间。其中,47例(33.1%)在医院死亡。95例出院患者中的94例接受了随访(中位随访时间为30.6个月),94例中的44例(46.8%)在随访期间死亡。50例幸存者的杜克活动状态指数中位数在可能的58.2分中为26分。142例长期住院患者使用了全部2618例患者ICU总住院天数的50%和ICU总直接费用的48%。

结论

许多长期重症监护幸存者在出院后不久死亡,许多长期幸存者功能状态较差。因此,出院对于这些患者来说是一个不完整的预后衡量指标,更长时间的随访更为合适。需要长期重症监护的患者数量相对较少,但却消耗了不成比例的ICU总费用和医院总直接费用。

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