Rasmussen B B, Pedersen B V, Thorpe S M, Rose C
Cancer Res. 1985 Mar;45(3):1428-30.
The content of elastic tissue has been evaluated in 171 primary breast carcinomas. Of the tumors, 35% had no or very little elastic tissue in the malignant areas, 42% presented with medium elastosis, and 22% had gross elastosis. The occurrence of elastin has been related to different prognostic factors. An increasing amount of elastin was found with increasing amounts of estrogen receptor (p = 0.0003), while there was only a slight correlation to the progesterone receptor content. Furthermore, the highly differentiated tumors contained more elastin in their tumor tissue than the poorly differentiated tumors (p = 0.003), and parous women had significantly more elastin than nonparous women (p = 0.02). The presence of elastin was not, however, of any demonstrable prognostic significance.
对171例原发性乳腺癌的弹性组织含量进行了评估。在这些肿瘤中，35%的恶性区域无弹性组织或仅有极少弹性组织，42%表现为中度弹性组织增生，22%有明显弹性组织增生。弹性蛋白的出现与不同的预后因素有关。随着雌激素受体含量的增加，弹性蛋白的含量也增加（p = 0.0003），而与孕激素受体含量仅有轻微相关性。此外，高分化肿瘤的肿瘤组织中弹性蛋白含量高于低分化肿瘤（p = 0.003），经产妇的弹性蛋白含量明显高于未产妇（p = 0.02）。然而，弹性蛋白的存在并无明显的预后意义。
