Russo Thomas A, Lebreton Francois, McGann Patrick T
Emerg Infect Dis. 2025 Jan;31(1):1-3. doi: 10.3201/eid3101.241516.
Hypervirulent Klebsiella pneumoniae (hvKp) can cause life-threatening infections in healthy community members. HvKp infections often involve multiple sites, some of which are unusual for classical K. pneumoniae (cKp) infections, such as the central nervous system, eyes, and fascia. The acquisition of antimicrobial resistance by hvKp has resulted in concerns of an emerging superbug. This concern is magnified by increasing geographic dissemination and healthcare associated infections. Currently, diagnostic testing to differentiate hvKp from cKp is lacking, causing challenges for clinical care, surveillance, and research. Although imperfect, the detection of all 5 of the biomarkers iucA, iroB, peg-344, rmpA, and rmpA2 is the most accurate and pragmatic means to identify hvKp. We propose a working definition for hvKp that will enhance accuracy for diagnosis and surveillance, which will aid in preventing the spread of hvKp.
高毒力肺炎克雷伯菌（hvKp）可在健康社区成员中引起危及生命的感染。HvKp感染常累及多个部位，其中一些部位在经典肺炎克雷伯菌（cKp）感染中并不常见，如中枢神经系统、眼睛和筋膜。HvKp获得抗菌药物耐药性引发了对一种新兴超级细菌的担忧。这种担忧因地理传播范围扩大和医疗保健相关感染而加剧。目前，缺乏区分hvKp和cKp的诊断检测方法，给临床护理、监测和研究带来了挑战。尽管并不完美，但检测iucA、iroB、peg - 344、rmpA和rmpA2这5种生物标志物是识别hvKp最准确、最实用的方法。我们提出了一个hvKp的工作定义，这将提高诊断和监测的准确性，有助于预防hvKp的传播。
