非洲癌症患者的抑郁、焦虑及相关因素；一项系统评价与荟萃分析研究

Depression, anxiety and associated factors among cancer patients in Africa; a systematic review and meta-analysis study.

作者信息

Nakie Girum, Melkam Mamaru, Takelle Girmaw Medfu, Fentahun Setegn, Rtbey Gidey, Andualem Fantahun, Kibralew Getasew, Wassie Yilkal Abebaw, Kassa Mulat Awoke, Tinsae Techilo, Tadesse Gebresilassie

机构信息

Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

BMC Psychiatry. 2024 Dec 23;24(1):939. doi: 10.1186/s12888-024-06389-5.

DOI:10.1186/s12888-024-06389-5

PMID:39716105

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668085/

Abstract

BACKGROUND

Depression and anxiety are the most common types of mental disorders among cancer patients. Many research studies carried out in African countries indicate that anxiety and depression are highly prevalent, but the results vary across regions. Thus, this study aimed to estimate the pooled prevalence and associated factors of depression and anxiety among cancer patients in Africa.

METHODS

The databases EMBASE, PubMed, African Journals Online, and Google Scholar were used to identify articles. This systematic review and meta-analysis included 32 (31 for depression and 25 for anxiety) original articles from 11 African countries. To detect publication bias, Egger regression tests and funnel plot analysis were employed. A sensitivity analysis and a subgroup analysis were carried out.

RESULTS

The pooled prevalence of depression and anxiety among cancer patients was found to be 53.21% (95% CI: 47.47-58.94) and 53.32% (95% CI: 46.85, 59.80) respectively. Across regions, the prevalence of depression among cancer patients was 60.03 (95% CI: 55.85-64.21), 53.59 (95% CI: 45.31-61.87), and 43.92 (95% CI: 36.17-51.67) in North, East, and West Africa, respectively. The pooled prevalence of anxiety among cancer patients was 64.85 (95% CI: 54.81-74.88) in North Africa, 49.53 (95% CI: 40.72-58.33) in East Africa, and 46.23 (95% CI: 38.98-53.48) in West Africa. Advanced stages of cancer (AOR = 3.8; 95% CI: 1.73, 8.42), less educated (AOR = 2.57; 95% CI: 1.28-5.14), and having no financial support (AOR = 2.03; 95% CI: 1.12, 3.67) were factors associated with depression. Advanced stages of cancer (AOR = 5.44; 95% CI: 1.95, 15.18) and no financial assistance (AOR = 2.88; 95% CI: 1.79, 4.63) were factors associated with anxiety.

CONCLUSION

Depression and anxiety among cancer patients are highly prevalent in Africa. Being at an advanced stage of cancer, low educational attainment, and not having financial support were all associated with depression symptoms; in addition, having advanced cancer and not having financial support were also associated with anxiety symptoms. Therefore, it is critical to screen cancer patients for anxiety and depression and provide them with appropriate interventions when these conditions arise.

摘要

背景

抑郁和焦虑是癌症患者中最常见的精神障碍类型。在非洲国家开展的许多研究表明，焦虑和抑郁非常普遍，但各地区的结果有所不同。因此，本研究旨在评估非洲癌症患者中抑郁和焦虑的合并患病率及相关因素。

方法

使用EMBASE、PubMed、非洲在线期刊和谷歌学术数据库来识别文章。本系统评价和荟萃分析纳入了来自11个非洲国家的32篇（抑郁相关31篇，焦虑相关25篇）原创文章。采用Egger回归检验和漏斗图分析来检测发表偏倚。进行了敏感性分析和亚组分析。

结果

发现癌症患者中抑郁和焦虑的合并患病率分别为53.21%（95%置信区间：47.47 - 58.94）和53.32%（95%置信区间：46.85，59.80）。在各地区，北非、东非和西非癌症患者中抑郁的患病率分别为60.03（95%置信区间：55.85 - 64.21）、53.59（95%置信区间：45.31 - 61.87）和43.92（95%置信区间：36.17 - 51.67）。北非、东非和西非癌症患者中焦虑的合并患病率分别为64.85（95%置信区间：54.81 - 74.88）、49.53（95%置信区间：40.72 - 58.33）和46.23（95%置信区间：38.98 - 53.48）。癌症晚期（比值比 = 3.8；95%置信区间：1.73，8.42）、受教育程度较低（比值比 = 2.57；95%置信区间：1.28 - 5.14）以及没有经济支持（比值比 = 2.03；95%置信区间：1.12，3.67）是与抑郁相关的因素。癌症晚期（比值比 = 5.44；95%置信区间：1.95，15.18）和没有经济援助（比值比 = 2.88；95%置信区间：1.79，4.63）是与焦虑相关的因素。