Törnkvist H, Bauer F C, Nilsson O S
Clin Orthop Relat Res. 1985 Mar(193):264-70.
The effect of indomethacin on heterotopic and orthotopic bone formation in rats was analyzed with respect to dose and time of initiation of drug administration. Three weeks after implantation of demineralized bone matrix, the ash weight of implants from animals receiving the highest doses of indomethacin was approximately 25% lower than that of controls. The ash weight of implants was only affected in rats receiving indomethacin from the week before implantation or from the time of implantation. In a separate study, no effect on the rate of resorption measured by elimination of 3H-proline and 45Ca or on the amount of ash could be detected. Orthotopic bone remained unaffected by indomethacin treatment. The study showed that in order to inhibit experimental new bone formation, indomethacin must be present before or at the time of implantation of demineralized bone matrix.
就药物给药的剂量和起始时间，分析了吲哚美辛对大鼠异位和原位骨形成的影响。脱矿骨基质植入三周后，接受最高剂量吲哚美辛的动物植入物的灰重比对照组低约25%。仅在植入前一周或植入时接受吲哚美辛的大鼠中，植入物的灰重受到影响。在另一项研究中，未检测到对通过消除3H-脯氨酸和45Ca测量的吸收速率或灰分量的影响。原位骨不受吲哚美辛治疗的影响。该研究表明，为了抑制实验性新骨形成，吲哚美辛必须在脱矿骨基质植入前或植入时存在。
