Rahman Md Kaisar, Awosile Babafela
Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, USA.
Infect Dis Now. 2025 Feb;55(1):105019. doi: 10.1016/j.idnow.2024.105019. Epub 2024 Dec 21.
This study aimed to explore the distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.
We analyzed data from 83 countries through the Antimicrobial Testing Leadership and Surveillance program, spanning 2004 to 2021. We calculated the proportion of each β-lactamase gene across nine bacterial species and generated a heatmap for β-lactamase genes with a frequency of ≥ 1 % in at least one species.
A total of 359 β-lactamase genes were identified, with the highest proportion found in Klebsiella spp. (61.84 %, n = 222), followed by Escherichiacoli (47.63 %, n = 171), and Proteus spp. (20.61 %, n = 74). The ESBL gene bla was most prevalent in Klebsiella spp. (62.39 %) and E.coli (53.16 %). The carbapenemase genes bla, bla, and bla were notably higher in Providencia spp. (59.47 %), Raoultella spp. (45.45 %), and Serratia spp. (25.24 %), respectively.
Further surveillance and research are needed to investigate the diversity of β-lactamase genes across One Health interfaces.
本研究旨在探讨人类临床样本中肠杆菌科细菌β-内酰胺酶基因的分布情况。
我们通过抗菌药物检测领导力与监测项目分析了来自83个国家的数据，时间跨度为2004年至2021年。我们计算了9种细菌中每种β-内酰胺酶基因的比例，并为在至少一种细菌中频率≥1%的β-内酰胺酶基因生成了热图。
共鉴定出359个β-内酰胺酶基因，其中在克雷伯菌属中比例最高（61.84%，n = 222），其次是大肠杆菌（47.63%，n = 171）和变形杆菌属（20.61%，n = 74）。ESBL基因bla在克雷伯菌属（62.39%）和大肠杆菌（53.16%）中最为普遍。碳青霉烯酶基因bla、bla和bla分别在普罗威登斯菌属（59.47%）、拉乌尔菌属（45.45%）和沙雷菌属（25.24%）中显著更高。
需要进一步的监测和研究来调查“同一个健康”界面中β-内酰胺酶基因的多样性。
