Gholamali Iman, Yadollahi Mehdi
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran; Department of Chemistry, North Tehran Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran.
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
Int J Biol Macromol. 2025 Feb;290:139044. doi: 10.1016/j.ijbiomac.2024.139044. Epub 2024 Dec 21.
Hydrogels are adaptable substances with a 3D framework able to hold large quantities of water, which is why they are ideal for use in the field of biomedicine. This research project focused on creating a new hydrogel combining carboxymethyl chitosan (CMCS), graphene quantum dots (GQDs), pectin (Pe), and MIL-88 for precise and controlled release of the cancer drug doxorubicin (DOX). The creation of CMCS/GQDs@Pe/MIL-88 hydrogel beads was achieved through an eco-friendly one-step synthesis method. The hydrogel beads were then analyzed using various techniques including FE-SEM, EDX, FT-IR, XRD, BET surface area, DLS, and zeta potential measurements. The hydrogel beads showed great swelling ability and controlled breakdown in different pH environments, mimicking the conditions of the gastrointestinal tract and body. Research on drug loading and release showed that the hydrogel components can be adjusted to control the release of DOX. Cytotoxicity tests in a lab setting using K562 cells demonstrated successful delivery of DOX and the ability to target cancer cells specifically while reducing negative effects. Adding GQDs improved both the imaging abilities and the stability and mechanical characteristics of the hydrogel. This research indicates that the CMCS/GQDs@Pe/MIL-88 combination hydrogel beads show great potential for advanced drug delivery systems, especially in cancer treatment.
水凝胶是一种具有三维框架的适应性物质，能够容纳大量水分，这就是它们在生物医学领域应用的理想之选。本研究项目专注于创建一种新型水凝胶，它结合了羧甲基壳聚糖（CMCS）、石墨烯量子点（GQDs）、果胶（Pe）和MIL-88，用于精确控制癌症药物阿霉素（DOX）的释放。通过一种环保的一步合成方法制备了CMCS/GQDs@Pe/MIL-88水凝胶珠。然后使用包括场发射扫描电子显微镜（FE-SEM）、能谱仪（EDX）、傅里叶变换红外光谱仪（FT-IR）、X射线衍射仪（XRD）、比表面积分析仪（BET）、动态光散射仪（DLS）和zeta电位测量仪等各种技术对水凝胶珠进行了分析。水凝胶珠在不同pH环境下表现出极大的溶胀能力和可控的分解，模拟了胃肠道和身体的条件。药物负载和释放研究表明，可以调整水凝胶成分以控制DOX的释放。在实验室环境中使用K562细胞进行的细胞毒性测试证明了DOX的成功递送以及特异性靶向癌细胞同时减少负面影响的能力。添加GQDs改善了水凝胶的成像能力以及稳定性和机械特性。这项研究表明，CMCS/GQDs@Pe/MIL-88复合水凝胶珠在先进药物递送系统中具有巨大潜力，尤其是在癌症治疗方面。
