Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science, Tabriz, Iran.
Int J Biol Macromol. 2018 Sep;116:54-63. doi: 10.1016/j.ijbiomac.2018.04.140. Epub 2018 Apr 27.
The present project describes the facile preparation of novel pH-sensitive bio-nanocomposite hydrogel beads based on chitosan (CH) and GO-Ag nanohybrid particles for controlled release of anti-cancer drugs such as doxorubicin (DOX). The loading efficiency of doxorubicin into test beads was measured via UV-vis spectroscopy analysis and was found to be high. The formation of silver nanoparticles on the GO sheets and structural characteristics were evaluated via FT-IR, TEM, XRD, and SEM techniques. In addition, the antibacterial activity, swelling and drug release profiles of prepared nanocomposite beads were evaluated. Also, in vitro drug release test was performed in order to investigate the efficiency of CH/GO-Ag nanocomposite hydrogel beads as a drug carrier for controlled release of anti-cancer drugs such as doxorubicin (DOX). A more sustained and controlled drug release profile was observed for CH/GO-Ag nanocomposite hydrogel beads that enhanced by increasing the GO-Ag nanohybrid particles content.
本项目描述了一种简便的方法，用于制备基于壳聚糖（CH）和 GO-Ag 纳米杂化粒子的新型 pH 敏感的生物纳米复合水凝胶珠，用于控制释放抗癌药物，如阿霉素（DOX）。通过紫外可见光谱分析测量阿霉素在测试珠中的负载效率，发现负载效率很高。通过 FT-IR、TEM、XRD 和 SEM 技术评估了银纳米粒子在 GO 片上的形成和结构特征。此外，还评估了制备的纳米复合珠的抗菌活性、溶胀和药物释放特性。此外，还进行了体外药物释放试验，以研究 CH/GO-Ag 纳米复合水凝胶珠作为抗癌药物（如阿霉素（DOX））的控释药物载体的效率。增加 GO-Ag 纳米杂化粒子的含量可以增强 CH/GO-Ag 纳米复合水凝胶珠的药物释放特性，使其具有更持续和更可控的药物释放曲线。
