Sawalmeh Ayham, Johansson Emily White, Kostas Danis, Hjaijeh Dia'a
Preventive Medicine Department, Palestinian Ministry of Health, Nablus, Palestine.
Mediterranean and Black Sea Programme in Intervention Epidemiology Training (MediPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
J Viral Hepat. 2025 Jan;32(1):e14055. doi: 10.1111/jvh.14055.
Hepatitis B is an infectious disease that inflicts high health and economic costs on the healthcare system. Poor adherence to treatment increases that cost. We aimed to assess the levels of knowledge, attitudes and practices (KAP) among patients in the West Bank, Palestine, and identify factors associated with good adherence. We conducted a cross-sectional study surveying hepatitis B patients visiting primary healthcare during October 2022 until June 2023 using an interviewer-administered questionnaire covering qualitative and quantitative aspects regarding hepatitis B. We considered adherence as good if participants received > 90% of their monthly prescription antiviral doses. Among 386 participants, the median age was 45 years (range 20-81); 80% had good adherence to treatment. Mean knowledge score was 11.4 (on a 13-point scale), mean attitude score was 3.4 (on a 4-point scale), mean practices score was 6 (on a 7-point scale) and the mean overall KAP score was 21.8 (on a 24-point scale). KAP components (Cronbach alpha = 0.820) were correlated with good adherence (p < 0.001). After adjustment for other factors, participants with good KAP scores had better adherence to treatment than those without (prevalence ratio: 1.41, 95% CI: 1.10-1.84, p-value = 0.011). We recommend investment in education and awareness campaigns to improve adherence.
乙型肝炎是一种传染病，给医疗系统带来了高昂的健康和经济成本。治疗依从性差会增加成本。我们旨在评估巴勒斯坦西岸地区患者的知识、态度和行为（KAP）水平，并确定与良好依从性相关的因素。我们进行了一项横断面研究，在2022年10月至2023年6月期间，使用一份涵盖乙型肝炎定性和定量方面的访谈式问卷，对前来初级医疗保健机构就诊的乙型肝炎患者进行调查。如果参与者每月服用的抗病毒药物处方剂量超过90%，我们就认为其依从性良好。在386名参与者中，年龄中位数为45岁（范围20 - 81岁）；80%的人治疗依从性良好。知识平均得分是11.4（满分13分），态度平均得分是3.4（满分4分），行为平均得分是6（满分7分），总体KAP平均得分是21.8（满分24分）。KAP各组成部分（Cronbach阿尔法系数 = 0.820）与良好依从性相关（p < 0.001）。在对其他因素进行调整后，KAP得分高的参与者比得分低的参与者治疗依从性更好（患病率比：1.41，95%置信区间：1.10 - 1.84，p值 = 0.011）。我们建议投资开展教育和宣传活动以提高依从性。
