Zhou Jia, Ding Xiaoqi, Jia Xinmiao, Sun Hongli
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, People's Republic of China.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People's Republic of China.
Infect Drug Resist. 2024 Dec 19;17:5649-5661. doi: 10.2147/IDR.S493557. eCollection 2024.
This study investigated the clinical relevance, pathogenic mechanisms, and neurological involvement of subspecies () and subspecies (), with a focus on a severe case of meningitis complicated by septic shock.
A systematic review of 19 cases of neurological infections caused by ( or ) from 1971 to 2023 was conducted, supplemented by a detailed case report. Data on patient demographics, predisposing factors, clinical manifestations, diagnostic procedures, treatment, and outcomes were analyzed.
The reviewed cases involved 12 patients with and seven with . The median age was 53 years, and most patients had underlying conditions such as diabetes, malignancy, or cardiovascular disease. Neurological manifestations were common, with meningitis being diagnosed in 17 patients. Despite prompt antibiotic therapy, six patients (32%) died, highlighting the severe nature of these infections.
can cause severe neurological infections, particularly in immunocompromised patients. Early recognition and aggressive treatment are essential to improving outcomes. Advanced molecular diagnostic techniques, such as next-generation sequencing (NGS), are crucial in identifying and managing these infections.
本研究调查了亚种（）和亚种（）的临床相关性、致病机制及神经受累情况，重点关注1例严重的脑膜炎并发感染性休克病例。
对1971年至2023年期间19例由（或）引起的神经感染病例进行系统综述，并辅以详细的病例报告。分析患者人口统计学、易感因素、临床表现、诊断程序、治疗及结局等数据。
纳入综述的病例中，12例为感染，7例为感染。中位年龄为53岁，大多数患者有糖尿病、恶性肿瘤或心血管疾病等基础疾病。神经表现常见，17例患者诊断为脑膜炎。尽管及时给予抗生素治疗，仍有6例患者（32%）死亡，凸显了这些感染的严重性。
可引起严重的神经感染，尤其是在免疫功能低下的患者中。早期识别和积极治疗对改善结局至关重要。先进的分子诊断技术，如下一代测序（NGS），在识别和管理这些感染方面至关重要。
