Hu Yuyuan, Liu Yongping, Fu Jieting, Liu Yong, Wang Haiying, Song Ying
Department of Hematology, Affiliated Hospital of Shandong Second Medical University, Weifang 261000, China.
Shandong Second Medical University, Weifang 261053, China.
iScience. 2024 Nov 23;27(12):111356. doi: 10.1016/j.isci.2024.111356. eCollection 2024 Dec 20.
Children are the main susceptible group to acute lymphoblastic leukemia (ALL), and the lack of sufficient data has impeded a comprehensive understanding of its global impact. This study analyzed the annual numbers and rates of incidence, deaths, and disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, disaggregated by age group, gender, and socio-demographic index (SDI) at the global, regional, and national levels, based on the 2021 Global Burden of Disease (GBD) database. Although global deaths and DALYs rates for childhood ALL showed declining trends, the incidence rate fluctuated. Incidence rates in high SDI regions were higher, but deaths and DALY rates were lower. Moreover, the burden in Sub-Saharan Africa and other low SDI countries was growing. The burden on boys has been higher than on girls in this period. This study underscored improving prevention and treatment measures are critical to control the persistent global burden of children ALL.
儿童是急性淋巴细胞白血病（ALL）的主要易感人群，而缺乏足够的数据阻碍了对其全球影响的全面了解。本研究基于2021年全球疾病负担（GBD）数据库，分析了1990年至2021年全球、区域和国家层面按年龄组、性别和社会人口指数（SDI）分类的儿童ALL的年发病数、发病率、死亡数和伤残调整生命年（DALYs）。尽管全球儿童ALL的死亡率和DALYs率呈下降趋势，但发病率波动较大。高SDI地区的发病率较高，但死亡率和DALYs率较低。此外，撒哈拉以南非洲和其他低SDI国家的负担正在增加。在此期间，男孩的负担一直高于女孩。本研究强调，改善预防和治疗措施对于控制全球持续存在的儿童ALL负担至关重要。
