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一名儿科患者使用甲氧氯普胺后出现急性斜颈反应:一份全面的病例报告及对当前知识的评估

Acute Torticollis Reaction Following Metoclopramide Use in a Pediatric Patient: A Comprehensive Case Report and Appraisal of Current Knowledge.

作者信息

Gabobe Nor Mohamed Farah, Salah Rayan Mohamed, Ahmed Mohammed A M, Hassan Sakariye Abdullahi, Farah Yusuf Mohamud Mohamed

机构信息

Faculty of Medicine, Mogadishu University, Mogadishu, Somalia.

Department of Pediatric, Kalkaal Hospital, Mogadishu, Somalia.

出版信息

Int Med Case Rep J. 2024 Dec 17;17:1037-1040. doi: 10.2147/IMCRJ.S484955. eCollection 2024.

Abstract

Dopamine receptor antagonists like metoclopramide are frequently used in a variety of clinical contexts to treat gastrointestinal disorders and control nausea and vomiting. However, it is associated with a high incidence of extrapyramidal side effects (EPS) in children, including dystonic movements and torticollis. This is the instance of a 9-year-old girl who developed abnormal movements of the neck and tongue, along with torticollis, within 48 hours of receiving intravenous metoclopramide for gastroenteritis. The metoclopramide therapy was discontinued, and supportive measures, including diphenhydramine, were initiated, resulting in the resolution of symptoms. This case highlights the importance of recognizing and managing metoclopramide-induced EPS in pediatric patients.

摘要

像甲氧氯普胺这样的多巴胺受体拮抗剂常用于各种临床情况,以治疗胃肠道疾病并控制恶心和呕吐。然而,它在儿童中与锥体外系副作用(EPS)的高发生率相关,包括肌张力障碍性运动和斜颈。这是一名9岁女孩的病例,她在因肠胃炎接受静脉注射甲氧氯普胺后48小时内出现颈部和舌头的异常运动以及斜颈。停用了甲氧氯普胺治疗,并开始采取包括苯海拉明在内的支持措施,症状得以缓解。该病例凸显了识别和处理儿科患者中由甲氧氯普胺引起的EPS的重要性。

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Metoclopramide induced acute dystonic reaction: A case report.甲氧氯普胺诱发的急性肌张力障碍反应:一例报告。
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本文引用的文献

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Metoclopramide in the treatment of diabetic gastroparesis.甲氧氯普胺治疗糖尿病性胃轻瘫。
Expert Rev Endocrinol Metab. 2010;5(5):653-662. doi: 10.1586/eem.10.41.

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