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大黄蒽醌抗肝癌机制及毒性的研究进展

Research Progress on the Anti-Liver Cancer Mechanism and Toxicity of Rhubarb Anthraquinone.

作者信息

Yu Linyuan, Qin Jinxing, Zhang Mei, Gao Yawen, Zhao Yongli

机构信息

Department of Pharmacy, Chengdu Integrative TCM & Western Medicine Hospital, Chengdu, Sichuan, 610095, People's Republic of China.

Department of Pharmacy, Sichuan Second Hospital of T.C.M, Chengdu, Sichuan, 610031, People's Republic of China.

出版信息

Drug Des Devel Ther. 2024 Dec 18;18:6089-6113. doi: 10.2147/DDDT.S489377. eCollection 2024.

DOI:10.2147/DDDT.S489377
PMID:39717199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11664478/
Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Rhubarb has the effect of breaking blood stasis and abnormal mass, and was often used to treat various tumor diseases including liver cancer in ancient China. Recipes containing rhubarb have anti-liver cancer properties and are still used today. However, the main components and mechanism of action of rhubarb against liver cancer are still unclear.

AIM OF THE REVIEW

To conduct a review of the anti-liver cancer effects and toxicity of rhubarb anthraquinones (AQs).

MATERIALS AND METHODS

This article reviewed the effects of rhubarb AQs in the treatment of liver cancer and the signaling pathways involved, and discussed the toxicity and pharmacokinetics of rhubarb AQs by searching the Web of Science, PubMed and CNKI databases.

RESULTS

Rhubarb (Rhei Radix et Rhizoma) is a traditional Chinese medicine that has been existed for thousands of years and is used as an anti-cancer drug. Modern pharmacological research shows that rhubarb AQs, as the main component of rhubarb, contains emodin, rhein, chrysophanol, physcione and aloe-emodin, which has anti-liver cancer effects and can be considered as a potential therapeutic drug for liver cancer. However, many modern studies have shown that rhubarb AQs have certain toxicity, which hinders in-depth research on rhubarb AQs.

CONCLUSION

Rhubarb AQs can be used as a potential anti-liver cancer drug, but its research still has many limitations. Strengthening research on related experiments and finding a balance between toxicity and efficacy are all directions worth studying in the future.

摘要

民族药理学相关性

大黄具有破血逐瘀、消积的作用，在中国古代常被用于治疗包括肝癌在内的各种肿瘤疾病。含大黄的方剂具有抗肝癌特性，至今仍在使用。然而，大黄抗肝癌的主要成分和作用机制仍不清楚。

综述目的

对大黄蒽醌类化合物（AQs）的抗肝癌作用及毒性进行综述。

材料与方法

通过检索Web of Science、PubMed和CNKI数据库，本文综述了大黄蒽醌类化合物在治疗肝癌方面的作用及涉及的信号通路，并讨论了大黄蒽醌类化合物的毒性和药代动力学。

结果

大黄是一种已存在数千年的传统中药，被用作抗癌药物。现代药理学研究表明，大黄蒽醌类化合物作为大黄的主要成分，含有大黄素、大黄酸、 Chrysophanol、大黄酚和芦荟大黄素，具有抗肝癌作用，可被视为肝癌的潜在治疗药物。然而，许多现代研究表明，大黄蒽醌类化合物具有一定毒性，这阻碍了对大黄蒽醌类化合物的深入研究。

结论

大黄蒽醌类化合物可作为潜在的抗肝癌药物，但其研究仍有许多局限性。加强相关实验研究，在毒性和疗效之间找到平衡，都是未来值得研究的方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/8b65f9dc8389/DDDT-18-6089-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/153e27214729/DDDT-18-6089-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/0d20db69349a/DDDT-18-6089-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/52d2e4cb39f5/DDDT-18-6089-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/8b65f9dc8389/DDDT-18-6089-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/153e27214729/DDDT-18-6089-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/0c1b96e613cf/DDDT-18-6089-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/a351f1b5dca4/DDDT-18-6089-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/3b3edc315a1c/DDDT-18-6089-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/0d20db69349a/DDDT-18-6089-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/52d2e4cb39f5/DDDT-18-6089-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c55/11664478/8b65f9dc8389/DDDT-18-6089-g0007.jpg

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本文引用的文献

1
Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms.天然产物对肝癌的治疗作用及其潜在机制。
Nutrients. 2024 May 27;16(11):1642. doi: 10.3390/nu16111642.
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Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition).原发性肝癌诊疗指南（2022年版）
Liver Cancer. 2023 Apr 5;12(5):405-444. doi: 10.1159/000530495. eCollection 2023 Oct.
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Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.通过网络药理学和细胞实验探索芦荟大黄素治疗肝癌的机制。
Front Pharmacol. 2023 Oct 12;14:1238841. doi: 10.3389/fphar.2023.1238841. eCollection 2023.
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Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.大黄酸靶向热休克蛋白70（HSP70）伴侣蛋白可使肝癌对青蒿素衍生物敏感。
Phytomedicine. 2024 Jan;122:155156. doi: 10.1016/j.phymed.2023.155156. Epub 2023 Oct 20.
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Effect of emodin combined with cisplatin on the invasion and migration of HepG2 hepatoma cells.大黄素联合顺铂对 HepG2 肝癌细胞侵袭和迁移的影响。
J Physiol Pharmacol. 2023 Aug;74(4). doi: 10.26402/jpp.2023.4.04. Epub 2023 Oct 16.
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Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through miRNA-370/PIM1 axis-regulated glycolysis.大黄素甲醚通过miRNA-370/PIM1轴调控的糖酵解增加肝细胞癌对索拉非尼的敏感性。
World J Gastrointest Oncol. 2023 Aug 15;15(8):1400-1411. doi: 10.4251/wjgo.v15.i8.1400.
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Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties.从海洋真菌中分离出的蒽醌类化合物丹蒽醌是一种新型血管生成抑制剂，具有有趣的抗肿瘤和抗氧化特性。
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Study on the mechanism of acute liver injury protection in Rhubarb anthraquinone by metabolomics based on UPLC-Q-TOF-MS.基于超高效液相色谱-四极杆飞行时间质谱代谢组学的大黄蒽醌对急性肝损伤保护机制的研究
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