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毛发移植术后出现的切割性蜂窝织炎。

Dissecting Cellulitis Presenting After Hair Restoration Surgery.

作者信息

Guerrero-González Guillermo A, González-Martínez Gerardo, Valdez-Zertuche Jair A

机构信息

Dermatologic Surgery, Pango Dermatología, Monterrey, MEX.

Dermatology, Hospital Universitario "Dr. José Eleuterio González", Nuevo León, MEX.

出版信息

Cureus. 2024 Nov 23;16(11):e74304. doi: 10.7759/cureus.74304. eCollection 2024 Nov.

DOI:10.7759/cureus.74304
PMID:39717299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11665738/
Abstract

Dissecting cellulitis (DC) of the scalp is a chronic inflammatory condition marked by neutrophilic cicatricial alopecia, often linked to staphylococcal antigens. This case report details a 34-year-old male with scarring acne who developed DC following follicular unit extraction (FUE) approximately four months prior. Trichoscopic examination revealed brown pigmented dots, erythema, and melicerous crusts. Abscess drainage yielded negative bacterial cultures, leading to a diagnosis of DC. The patient was treated with isotretinoin (20 mg/day), dutasteride (0.5 mg/day), intralesional steroid injections, and salicylic acid-based shampoo. After four months, the patient exhibited significant improvement, with trichoscopic findings showing regrowing hairs and no abnormal hair loss. DC, though commonly associated with other follicular occlusion disorders, has not been previously reported following FUE, indicating a need for awareness of this potential complication. The efficacy of isotretinoin and the emerging role of dutasteride in managing DC highlight the importance of early diagnosis and personalized treatment. Trichoscopy is crucial for diagnosis and monitoring, emphasizing the need for prompt intervention to prevent scarring alopecia. Caution is advised when considering FUE in patients with severe inflammatory acne due to the risk of developing DC.

摘要

头皮分割性蜂窝织炎(DC)是一种慢性炎症性疾病,其特征为中性粒细胞瘢痕性脱发,常与葡萄球菌抗原有关。本病例报告详细介绍了一名34岁患有瘢痕性痤疮的男性,他在大约四个月前进行毛囊单位提取(FUE)后患上了DC。皮肤镜检查发现有褐色色素沉着点、红斑和脓性结痂。脓肿引流的细菌培养结果为阴性,从而诊断为DC。该患者接受了异维A酸(20毫克/天)、度他雄胺(0.5毫克/天)、皮损内注射类固醇以及水杨酸洗发水治疗。四个月后,患者有显著改善,皮肤镜检查结果显示有毛发再生且无异常脱发。DC虽然通常与其他毛囊闭锁性疾病相关,但此前尚未有FUE后发生DC的报道,这表明需要认识到这种潜在并发症。异维A酸的疗效以及度他雄胺在治疗DC中日益凸显的作用强调了早期诊断和个性化治疗的重要性。皮肤镜检查对于诊断和监测至关重要,强调了及时干预以预防瘢痕性脱发的必要性。由于存在发生DC的风险,对于患有严重炎症性痤疮的患者,在考虑进行FUE时应谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ba/11665738/81abce4595e2/cureus-0016-00000074304-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ba/11665738/5c2c04e47287/cureus-0016-00000074304-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ba/11665738/81abce4595e2/cureus-0016-00000074304-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ba/11665738/5c2c04e47287/cureus-0016-00000074304-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ba/11665738/81abce4595e2/cureus-0016-00000074304-i02.jpg

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本文引用的文献

1
Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review.度他雄胺治疗雄激素性脱发:最新综述
Dermatology. 2024;240(5-6):833-843. doi: 10.1159/000541395. Epub 2024 Sep 13.
2
A Case of Dissecting Cellulitis of the Scalp, Hidradenitis Suppurativa, and Conglobate Acne Successfully Treated with Secukinumab.司库奇尤单抗成功治疗头皮蜂窝织炎、化脓性汗腺炎和聚合性痤疮一例
Skin Appendage Disord. 2024 Jun;10(3):232-235. doi: 10.1159/000537914. Epub 2024 Mar 18.
3
Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia.
比较米诺地尔、非那雄胺和度他雄胺治疗雄激素性脱发。
J Dermatolog Treat. 2022 Nov;33(7):2946-2962. doi: 10.1080/09546634.2022.2109567. Epub 2022 Aug 15.
4
Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis.分析异维 A 酸治疗蜂窝织炎的疗效:文献回顾和荟萃分析。
Drugs R D. 2021 Mar;21(1):29-37. doi: 10.1007/s40268-020-00335-y. Epub 2021 Jan 2.
5
Trichoscopy findings in dissecting cellulitis.蜂窝织炎的毛发镜检查结果
An Bras Dermatol. 2019 Sep-Oct;94(5):608-611. doi: 10.1016/j.abd.2019.09.006. Epub 2019 Sep 30.
6
Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66-patient case series and proposal of classification.头皮滤泡炎(化脓性汗腺炎)解剖:66 例患者病例系列及分类建议。
J Dtsch Dermatol Ges. 2018 Oct;16(10):1219-1226. doi: 10.1111/ddg.13649. Epub 2018 Aug 31.
7
Clinical Outcome and Safety Profile of Patients Underwent Hair Transplantation Surgery by Follicular Unit Extraction.接受毛囊单位提取毛发移植手术患者的临床结果和安全性概况
JNMA J Nepal Med Assoc. 2018 Jan-Feb;56(209):540-543.
8
Epidemiology, clinical presentation and therapeutic approach in a multicentre series of dissecting cellulitis of the scalp.多中心头皮穿掘性蜂窝织炎系列研究中的流行病学、临床表现及治疗方法
J Eur Acad Dermatol Venereol. 2017 Apr;31(4):e199-e200. doi: 10.1111/jdv.13948. Epub 2016 Sep 18.
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Dissecting cellulitis of the scalp: a retrospective study of 51 patients and review of literature.头皮切割性蜂窝织炎:51例患者的回顾性研究及文献复习
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Dermatol Online J. 2014 May 16;20(5):22692.