Wang Bo, Huang Jie, Chen Li
Department of Paediatric Surgery, Tianjin Medical University General Hospital Tianjin, China.
Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Compr Psychoneuroendocrinol. 2024 Dec 2;20:100279. doi: 10.1016/j.cpnec.2024.100279. eCollection 2024 Nov.
Hashimoto's thyroiditis (HT) affects up to 10 % of the population and is a common cause of hypothyroidism, which can lead to depression and anxiety. However, it remains unclear whether HT directly causes these conditions or if they arise due to HT-induced hypothyroidism. The present review aims to offer meta-analytic insights into the relationship between depression and anxiety in patients with euthyroid HT.
A comprehensive search was conducted in PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Data, SinoMed, and VIP from their inception through May 2024. Case-control or cross-sectional studies examining the association between euthyroid HT and either depression, anxiety disorders, or both were included.
For depression, 1365 patients (694 HT vs. 671 controls) from 11 articles were analyzed; for anxiety, 1009 patients (516 HT vs. 493 controls) from 8 articles were included. HT patients had 2.5 times higher odds of anxiety disorders (OR = 2.52, 95 % CI: 1.66-3.82). The Beck Depression Inventory showed a WMD of 4.26 (95 % CI: 1.28-7.24) and the Beck Anxiety Inventory a WMD of 5.10 (95 % CI: 1.55-8.66).
The findings should be interpreted cautiously due to heterogeneity, potential publication bias, and variability in assessment tools, which may limit generalizability.
Euthyroid HT patients exhibit a higher prevalence of anxiety disorders compared to healthy control groups, and more susceptible to anxiety and depression symptoms based on the Beck Inventory. Thyroid antibodies themselves are also associated with depression and anxiety disorder.
桥本甲状腺炎（HT）影响着高达10%的人群，是甲状腺功能减退的常见原因，可导致抑郁和焦虑。然而，尚不清楚HT是否直接导致这些情况，还是它们因HT诱发的甲状腺功能减退而出现。本综述旨在对甲状腺功能正常的HT患者中抑郁与焦虑之间的关系提供荟萃分析见解。
从创刊至2024年5月，在PubMed、Embase、科学网、考克兰图书馆、中国知网、万方数据、中国生物医学文献数据库和维普资讯中进行了全面检索。纳入了检查甲状腺功能正常的HT与抑郁、焦虑症或两者之间关联的病例对照或横断面研究。
对于抑郁，分析了11篇文章中的1365例患者（694例HT患者与671例对照）；对于焦虑，纳入了8篇文章中的1009例患者（516例HT患者与493例对照）。HT患者患焦虑症的几率高2.5倍（OR = 2.52，95%CI：1.66 - 3.82）。贝克抑郁量表显示加权均数差为4.26（95%CI：1.28 - 7.24），贝克焦虑量表加权均数差为5.10（95%CI：1.55 - 8.66）。
由于异质性、潜在的发表偏倚和评估工具的变异性，这些发现应谨慎解释，这可能会限制其普遍性。
与健康对照组相比，甲状腺功能正常的HT患者焦虑症患病率更高，并且根据贝克量表更容易出现焦虑和抑郁症状。甲状腺抗体本身也与抑郁和焦虑症有关。
