桥本甲状腺炎女性的情感气质与躯体症状之间的关联。
Association between affective temperaments and psychosomatic symptoms in women with Hashimoto's thyroiditis.
机构信息
Academy of Applied Studies Belgrade Department of School of Applied Health Sciences, Belgrade, Serbia.
Department of Psychiatry, Facult of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
出版信息
PLoS One. 2023 Aug 15;18(8):e0290066. doi: 10.1371/journal.pone.0290066. eCollection 2023.
BACKGROUND
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disease of thyroid gland with a shared immunological mechanism with mood disorders. Affective temperament (AT) is a biologically determined personality trait that has been linked to mood disorders. The aim of this study was to examine the association between dominant AT and levels of psychosomatic symptoms in women newly diagnosed with HT in comparison to clinically healthy subjects.
METHODS
The observational cross-sectional study with nested case control study was involving 146 consecutive participants, who were divided into three groups. The two study groups consisted of women with HT (73), including 49 with hypothyroid HT and 24 with euthyroid HT, and the third group was a control group of healthy participants (73). The Serbian version of the TEMPS-A was utilized to assess AT, while the 4DSQ was used to measure psychosomatic symptoms.
RESULTS
The results showed that hyperthymic AT was dominant in all examined groups. The groups with HT differed from the control group in terms of depressive and cyclothymic AT. Furthermore, the study found higher levels of psychosomatic symptoms in the group with HT compared to the control group, with significant differences in distress (p = 0.005) and somatization (p = 0.023) levels. All AT was associated with levels of psychosomatic symptoms in subjects with hypothyroid HT. In contrast, in subjects with euthyroid HT, the association was only found between depressive and cyclothymic AT with distress and depression levels, as well as between somatization and cyclothymic AT. No association was found between AT and anxiety levels in subjects with euthyroid HT.
CONCLUSION
The research found differences between study groups in the association between AT and levels of psychosomatic symptoms. Further research with a larger sample size is necessary to more clearly define the associations between affective temperaments and psychosomatic symptoms in women with euthyroid and hypothyroid HT.
背景
桥本甲状腺炎（HT）是一种常见的甲状腺自身免疫性疾病，其发病机制与情绪障碍具有共同的免疫学机制。情感气质（AT）是一种生物学决定的人格特质，与情绪障碍有关。本研究旨在比较新诊断为 HT 的女性与临床健康受试者之间，主要 AT 与躯体症状水平之间的关联。
方法
本研究采用了观察性横断面研究和嵌套病例对照研究，共纳入了 146 名连续参与者，他们被分为三组。两个研究组包括 HT 患者（73 人），其中 49 人患有甲状腺功能减退型 HT，24 人患有甲状腺功能正常型 HT；第三组为健康对照组（73 人）。采用塞尔维亚版 TEMPS-A 评估 AT，采用 4DSQ 测量躯体症状。
结果
结果显示，所有检查组均以高反应性 AT 为主。HT 组与对照组在抑郁和环性 AT 方面存在差异。此外，与对照组相比，HT 组的躯体症状水平更高，差异具有统计学意义（焦虑：p = 0.005；抑郁：p = 0.023）。在甲状腺功能减退型 HT 患者中，所有 AT 与躯体症状水平均存在关联。相反，在甲状腺功能正常型 HT 患者中，仅发现抑郁和环性 AT 与焦虑、抑郁水平以及躯体化与环性 AT 与躯体化水平之间存在关联。在甲状腺功能正常型 HT 患者中，AT 与焦虑水平之间无关联。
结论
研究发现，在 AT 与躯体症状水平之间的关联方面，研究组之间存在差异。需要进一步开展更大样本量的研究，以更清楚地定义甲状腺功能正常和甲状腺功能减退型 HT 女性的情感气质与躯体症状之间的关联。
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